Xindu Hospital of Traditional Chinese Medicine, Chengdu Medical College, Chengdu, Sichuan, People's Republic of China.
Department of Geriatric Medicine and Neurology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, People's Republic of China.
Curr Neurovasc Res. 2023;20(2):230-236. doi: 10.2174/1567202620666230606100652.
Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus. Some previous studies have found an association between insulin resistance and migraine. The triglyceride glucose (TyG) index is used to assess insulin resistance. However, there is no report on the association between the TyG index and migraine.
We present a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to clarify the association between the TyG index and migraine.
Data was acquired from the NHANES. Migraine was diagnosed based on patient selfreport and prescription medication. Data were analyzed using the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the twopiecewise linear regression model. Empower software was used for all data analysis.
A total of 18704 participants were enrolled in this study, of which 209 were migraineurs. The rest were set as control. There was a statistically significant difference in mean age (p = 0.0222), gender (p < 0.0001), distribution of race (P < 0.0001), and drug usage between the two groups. However, there were no differences in type 2 diabetes mellitus, type 1 diabetes mellitus, total cholesterol, triglycerides, glucose, and TyG index between the two groups. According to logistic regression models, there was a linear relationship between TyG index and migraine in model 3 (odds ratio (OR = 0.54, p = 0.0165). particularly in female (OR= 0.51, p = 0.0202) or Mexican American (OR= 0.18, p = 0.0203). Moreover, there was no inflection point between the TyG index and migraine.
In conclusion, there was a linear relationship between the TyG index and migraine. A higher TyG index predicts a lower incidence of migraine, particularly in females and Mexican Americans. Meanwhile, there is no inflection point between the TyG index and migraine.
胰岛素抵抗是指胰岛素降低血糖的能力降低的现象，是 2 型糖尿病的特征。一些先前的研究发现胰岛素抵抗与偏头痛之间存在关联。甘油三酯-葡萄糖（TyG）指数用于评估胰岛素抵抗。然而，目前尚无关于 TyG 指数与偏头痛之间关联的报道。
我们从国家健康和营养调查（NHANES）中呈现一项横断面研究，以阐明 TyG 指数与偏头痛之间的关联。
数据来自 NHANES。偏头痛根据患者自述和处方药物进行诊断。使用加权线性回归模型、加权卡方检验、逻辑回归模型、平滑曲线拟合和两段线性回归模型进行数据分析。所有数据分析均使用 Empower 软件。
本研究共纳入 18704 名参与者，其中 209 名为偏头痛患者。其余参与者作为对照组。两组在平均年龄（p = 0.0222）、性别（p < 0.0001）、种族分布（P < 0.0001）和药物使用方面存在统计学差异。然而，两组在 2 型糖尿病、1 型糖尿病、总胆固醇、甘油三酯、血糖和 TyG 指数方面无差异。根据逻辑回归模型，在模型 3 中，TyG 指数与偏头痛之间存在线性关系（比值比（OR）= 0.54，p = 0.0165）。特别是在女性（OR= 0.51，p = 0.0202）或墨西哥裔美国人（OR= 0.18，p = 0.0203）中。此外，TyG 指数与偏头痛之间没有拐点。
总之，TyG 指数与偏头痛之间存在线性关系。较高的 TyG 指数预示着偏头痛的发生率较低，特别是在女性和墨西哥裔美国人中。同时，TyG 指数与偏头痛之间没有拐点。
