Sun Yunhan, Zhang Shun, Shen Yukai, Lu Haoyang, Zhao Xincan, Wang Xin, Wang Yongkai, Wang Taiping, Liu Bing, Yao Lan, Wen Jie
School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Eye Hospital of Shandong First Medical University, Jinan, Shandong, China.
Front Bioeng Biotechnol. 2024 Aug 5;12:1428793. doi: 10.3389/fbioe.2024.1428793. eCollection 2024.
Wound healing is a complicated obstacle, especially for chronic wounds. Mesenchymal stem cell-derived exosomes may be a promising cell-free approach for treating skin wound healing. Exosomes can accelerate wound healing by attenuating inflammation, promoting angiogenesis, cell proliferation, extracellular matrix production and remodeling. However, many issues, such as off-target effects and high degradation of exosomes in wound sites need to be addressed before applying into clinical therapy. Therefore, the bioengineering technology has been introduced to modify exosomes with greater stability and specific therapeutic property. To prolong the function time and the local concentration of exosomes in the wound bed, the use of biomaterials to load exosomes emerges as a promising strategy. In this review, we summarize the biogenesis and characteristics of exosomes, the role of exosomes in wound healing, and the therapeutic applications of modified-exosomes in wound healing. The challenges and prospects of exosomes in wound healing are also discussed.
伤口愈合是一个复杂的难题，尤其是对于慢性伤口而言。间充质干细胞衍生的外泌体可能是一种有前景的无细胞治疗皮肤伤口愈合的方法。外泌体可以通过减轻炎症、促进血管生成、细胞增殖、细胞外基质产生和重塑来加速伤口愈合。然而，在应用于临床治疗之前，许多问题，如脱靶效应和外泌体在伤口部位的高降解率，都需要得到解决。因此，已经引入生物工程技术来修饰外泌体，使其具有更高的稳定性和特定的治疗特性。为了延长外泌体在伤口床中的功能时间和局部浓度，利用生物材料负载外泌体成为一种有前景的策略。在这篇综述中，我们总结了外泌体的生物发生和特征、外泌体在伤口愈合中的作用，以及修饰外泌体在伤口愈合中的治疗应用。我们还讨论了外泌体在伤口愈合方面面临的挑战和前景。
