Yaghoubian Ali, Setoodehkhah Moslem, Parsa Fatemeh
Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan Kashan Iran
RSC Adv. 2024 Aug 19;14(36):26091-26102. doi: 10.1039/d4ra04365k. eCollection 2024 Aug 16.
This study reports a novel magnetic and porous nanocomposite, FeO@CS@UIO-66-NH(Zr), developed by growing a zirconium-based metal-organic framework on magnetite-chitosan. It is designed for targeted and delayed pantoprazole delivery, the nanocomposite exhibits pH-sensitive behavior and functions as an efficient nanocarrier. The synthesis process involved coating magnetite nanoparticles with chitosan, followed by the growth of UIO-66-NH(Zr) on the coated nanoparticles. The nanocomposite demonstrated high drug loading efficiency (DLE) in acetate buffer (pH 5.0) and deionized water, with loading percentages of 79% and 75%, respectively, within 48 hours. The corresponding drug loading content (DLC) was approximately 14% and 10%. The Freundlich and Langmuir models accurately described the multilayer adsorption behavior of pantoprazole on the nanocomposite's active sites. BET and EDX-map analyses confirmed that the drug was loaded into the nanocomposite's pores and uniformly adsorbed on its surface. The drug release kinetics were best described by the pseudo-second-order model. Due to its porosity, magnetic properties, and favorable drug loading characteristics, the FeO@CS@UIO-66-NH(Zr) nanocomposite shows potential as an efficient targeted drug delivery system for applications.
本研究报道了一种新型磁性多孔纳米复合材料FeO@CS@UIO-66-NH(Zr)，它是通过在磁铁矿-壳聚糖上生长锆基金属有机框架而制备的。该纳米复合材料专为靶向和延迟泮托拉唑递送而设计，具有pH敏感行为，并作为一种高效的纳米载体发挥作用。合成过程包括用壳聚糖包覆磁铁矿纳米颗粒，然后在包覆后的纳米颗粒上生长UIO-66-NH(Zr)。该纳米复合材料在醋酸盐缓冲液（pH 5.0）和去离子水中表现出较高的载药效率（DLE），在48小时内载药百分比分别为79%和75%。相应的载药量（DLC）约为14%和10%。Freundlich和Langmuir模型准确描述了泮托拉唑在纳米复合材料活性位点上的多层吸附行为。BET和EDX图谱分析证实药物被载入纳米复合材料的孔隙并均匀吸附在其表面。药物释放动力学最好用伪二级模型描述。由于其孔隙率、磁性和良好的载药特性，FeO@CS@UIO-66-NH(Zr)纳米复合材料显示出作为一种高效靶向药物递送系统的应用潜力。
