Ye Dan, Li Yuanyuan, Yan Kangkang, Peng Wenzhong
Department of Pharmacy, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, People's Republic of China.
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Infect Drug Resist. 2024 Aug 14;17:3561-3567. doi: 10.2147/IDR.S469837. eCollection 2024.
is a zoonotic pathogen that causes miscarriage, stillbirth, and sepsis of pregnancy in pregnant women when it infects humans. However, it rarely causes pneumonia in humans.
This case reports a case of severe pneumonia characterized by high fever and cough, and the disease rapidly progressed to dyspnea. The patient was treated with moxifloxacin and doxycycline. detected in bronchoscopy examination and bronchoalveolar lavage fluid (BALF) through metagenomic next-generation sequencing (mNGS)-DNA. A weak positive for () antigen was also found in the throat swab tested. Subsequently, we added mabaloxavir and replaced doxycycline with an intravenous infusion of omadacycline. After effective treatment, the patient developed a urinary tract infection, and the treatment plan was adjusted to meropenem combined with omadacycline. The patient's condition improved, and she was discharged on the 14th day of admission.
This is the first report of cases of non-pregnant female patients with infection pneumonia. Consequently, infections with can result in severe respiratory distress, disturbance of water and electrolyte balance, and abnormal liver function, which requires timely diagnosis and correct use of antibiotics by clinicians. Consequently, the mixed infection of and aggravated the complexity of the condition and treatment. Combining tetracycline and quinolone is effective for treating severe pneumonia with infection.
是一种人畜共患病原体，感染人类时可导致孕妇流产、死产和妊娠败血症。然而，它很少在人类中引起肺炎。
本病例报告了一例以高热和咳嗽为特征的重症肺炎，疾病迅速进展为呼吸困难。患者接受了莫西沙星和多西环素治疗。通过宏基因组下一代测序（mNGS）-DNA在支气管镜检查和支气管肺泡灌洗（BALF）中检测到。咽喉拭子检测中也发现（）抗原弱阳性。随后，我们加用了玛巴洛沙韦，并将多西环素替换为静脉输注奥马环素。经过有效治疗，患者发生了尿路感染，治疗方案调整为美罗培南联合奥马环素。患者病情好转，入院第14天出院。
这是首例非妊娠女性患者感染肺炎的病例报告。因此，感染可导致严重呼吸窘迫、水电解质平衡紊乱和肝功能异常，临床医生需要及时诊断并正确使用抗生素。因此，与的混合感染加重了病情和治疗的复杂性。四环素和喹诺酮联合使用对治疗感染引起的重症肺炎有效。
