宏基因组下一代测序有助于诊断男性患者由[具体病原体未给出]引起的肺炎：病例报告及文献综述
Metagenomic Next-Generation Sequencing Contributes to the Diagnosis of Pneumonia Caused by in a Male Patient: Case Report and Literature Review.
作者信息
Gong Fan, Chen Zhikui, Chang Jianyuan, Liu Jinlong, Wang Xiaobin, Mo Weisong, Tan Mengqin, Jiang Tao
机构信息
Department of Emergency Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People's Republic of China.
Department of Respiratory Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People's Republic of China.
出版信息
Infect Drug Resist. 2023 Jun 2;16:3463-3468. doi: 10.2147/IDR.S407741. eCollection 2023.
BACKGROUND
is generally considered as the main cause of ruminants abortion, but it rarely causes human infection resulting in abortion or pneumonia.
CASE PRESENTATION
We report a case of male patient with pneumonia caused by . Results of next generation sequencing (NGS) in the bronchoalveolar lavage fluid (BALF) indicated infection. The patient was treated with intravenous infusion of doxycycline. The clinical symptoms of this patient were ameliorated significantly, and all these improvement were indicated by laboratory parameters significantly. Shown as chest computed tomography (CT), most of the inflammation had been absorbed after doxycycline treatment.
CONCLUSION
mainly infects ruminants and occasionally humans. NGS has its own advantages of rapidity, sensitivity and specificity in detecting . Doxycycline exhibits a great therapeutic effect on pneumonia caused by .
背景
通常被认为是反刍动物流产的主要原因，但很少导致人类感染并引发流产或肺炎。
病例报告
我们报告一例由 引起的男性肺炎患者。支气管肺泡灌洗液（BALF）的下一代测序（NGS）结果表明存在 感染。该患者接受了静脉输注强力霉素治疗。该患者的临床症状明显改善，所有这些改善均由实验室参数显著表明。胸部计算机断层扫描（CT）显示，强力霉素治疗后大部分炎症已被吸收。
结论
主要感染反刍动物，偶尔感染人类。NGS在检测 方面具有快速、灵敏和特异的自身优势。强力霉素对由 引起的肺炎具有很好的治疗效果。
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