Rouientan Abdolreza, Alizadeh Otaghvar Hamidreza, Mahmoudvand Hossein, Tizmaghz Adnan
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran.
World J Plast Surg. 2019 Jan;8(1):116-119. doi: 10.29252/wjps.8.1.116.
Botulinum toxin (BTX) is also well-known as Botox is produced by a gram-positive anaerobic bacterium called Generally, clinical manifestations of BTX can be observed after consumption of contaminated food, from colonization of the infant gastrointestinal tract, as well as following the infection of the wound to this bacterium. There are seven types of this neurotoxin labeled as A, B, C (C1, C2), D, E, and F. Human botulinum is caused by types A, B, E and rarely F. The most common clinical symptoms of BTX in cosmetic goals are cervical dystonia, severe primary axillary hyperhidrosis, strabismus, neurogenic detrusor over-activity, chronic migraine, upper limb spasticity and blepharospasm. Botox has a wide range of therapeutic uses and occasionally patients receiving this treatment may experience botulism symptom including local and even distant and autonomic symptoms. Despite the efficacies of Botox in treatment of myriad neurologic and cosmetic conditions, it may carry some risk of sever adverse effects which may be the result of local or systemic spreading of the drug. Our patient was a 22 years old man who received Botox for axillary hyperhidrosis after two weeks, when most of generalized complications of botulinum toxin appeared. This case was introduced for being aware of dangerous complication of Botox. Pyridostigmine could relieve symptoms of the patient.
肉毒杆菌毒素(BTX),也被称为保妥适,由一种革兰氏阳性厌氧菌肉毒杆菌产生。一般来说,食用受污染食物、婴儿胃肠道定植该细菌以及伤口感染该细菌后,均可观察到BTX的临床表现。这种神经毒素有七种类型,分别标记为A、B、C(C1、C2)、D、E和F。人类肉毒中毒由A、B、E型以及罕见的F型引起。在美容领域,BTX最常见的临床症状是颈部肌张力障碍、严重原发性腋窝多汗症、斜视、神经源性逼尿肌过度活动、慢性偏头痛、上肢痉挛和眼睑痉挛。保妥适有广泛的治疗用途,偶尔接受这种治疗的患者可能会出现肉毒中毒症状,包括局部甚至远处及自主神经症状。尽管保妥适在治疗多种神经和美容疾病方面有效,但它可能存在一些严重不良反应的风险,这可能是药物局部或全身扩散的结果。我们的患者是一名22岁男性,在接受保妥适治疗腋窝多汗症两周后,出现了肉毒杆菌毒素的大多数全身性并发症。介绍该病例是为了让大家了解保妥适的危险并发症。新斯的明可以缓解患者的症状。