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Rare Complication of Botox Injection: A Case Report.肉毒杆菌毒素注射的罕见并发症:一例报告
World J Plast Surg. 2019 Jan;8(1):116-119. doi: 10.29252/wjps.8.1.116.
2
[Botulinum toxin treatment of hip adductor spasticity in multiple sclerosis].[肉毒杆菌毒素治疗多发性硬化症患者的髋内收肌痉挛]
Wien Klin Wochenschr. 2001;113 Suppl 4:20-4.
3
[Botulism toxin in practice].[肉毒杆菌毒素的实际应用]
Ann Readapt Med Phys. 2003 Jul;46(6):386-8. doi: 10.1016/s0168-6054(03)00131-4.
4
Pyridostigmine for reversal of severe sequelae from botulinum toxin injection.吡啶斯的明用于逆转肉毒杆菌毒素注射所致严重后遗症。
J Voice. 2014 Nov;28(6):830-4. doi: 10.1016/j.jvoice.2014.04.010. Epub 2014 Jul 5.
5
BOTOX injection to treat strabismus after infant botulism type B infection.肉毒杆菌毒素注射用于治疗B型婴儿肉毒中毒感染后的斜视。
Am J Ophthalmol Case Rep. 2020 Aug 28;20:100895. doi: 10.1016/j.ajoc.2020.100895. eCollection 2020 Dec.
6
Urologic applications of botox.肉毒杆菌毒素在泌尿外科的应用
Curr Urol Rep. 2005 Nov;6(6):419-23. doi: 10.1007/s11934-005-0035-0.
7
Botulinum neurotoxin serotype A: a clinical update on non-cosmetic uses.A型肉毒杆菌神经毒素:非美容用途的临床最新进展
Am J Health Syst Pharm. 2004 Nov 15;61(22 Suppl 6):S11-23. doi: 10.1093/ajhp/61.suppl_6.S11.
8
Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect.用于减少面部皱纹外观的A型肉毒杆菌毒素(保妥适):临床应用和药理学方面的文献综述
Clin Cosmet Investig Dermatol. 2019 Apr 10;12:223-228. doi: 10.2147/CCID.S202919. eCollection 2019.
9
Botulinum toxin A: its expanding role in dermatology and esthetics.A型肉毒杆菌毒素:其在皮肤科和美容领域不断扩大的作用。
Am J Clin Dermatol. 2003;4(9):609-16. doi: 10.2165/00128071-200304090-00003.
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Comparison of botulinum neurotoxin preparations for the treatment of cervical dystonia.用于治疗颈部肌张力障碍的肉毒杆菌神经毒素制剂的比较。
Clin Ther. 2007 Jul;29(7):1325-37. doi: 10.1016/j.clinthera.2007.07.020.

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1
From Botox Party to Botulism: A Case Report and Public Health Warning on Adulterated Botulinum Toxin Injection.从肉毒杆菌派对到肉毒中毒:一例关于掺假肉毒毒素注射的病例报告及公共卫生警示
Cureus. 2024 Aug 28;16(8):e68016. doi: 10.7759/cureus.68016. eCollection 2024 Aug.
2
Self-Administered Botulinum Injection Causing Rare Masquerade of Systemic Botulism.自我注射肉毒杆菌导致罕见的全身性肉毒中毒伪装。
Cureus. 2024 Jul 20;16(7):e64976. doi: 10.7759/cureus.64976. eCollection 2024 Jul.
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A severe case of iatrogenic botulism associated with COVID-19 infection.一例与新冠病毒感染相关的严重医源性肉毒中毒病例。
Heliyon. 2024 May 31;10(11):e32237. doi: 10.1016/j.heliyon.2024.e32237. eCollection 2024 Jun 15.
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The efficacy and safety of a fractional microneedle radiofrequency device for the treatment of axillary hyperhidrosis: clinical prospective pilot study.一种用于治疗腋窝多汗症的微针射频设备的疗效和安全性:临床前瞻性试点研究。
Lasers Med Sci. 2022 Apr;37(3):1559-1566. doi: 10.1007/s10103-021-03404-z. Epub 2021 Aug 28.

本文引用的文献

1
An update on new and unique uses of botulinum toxin in movement disorders.肉毒杆菌毒素在运动障碍中的新独特用途的最新进展。
Toxicon. 2018 Jun 1;147:84-88. doi: 10.1016/j.toxicon.2017.09.003. Epub 2017 Sep 6.
2
Botulinum toxin the poison that heals: A brief review.肉毒杆菌毒素——治愈之毒:简要综述
Natl J Maxillofac Surg. 2016 Jan-Jun;7(1):10-16. doi: 10.4103/0975-5950.196133.
3
AAN Updates Guidelines on the Uses of Botulinum Neurotoxin.美国神经病学学会更新肉毒杆菌神经毒素使用指南。
Am Fam Physician. 2017 Feb 1;95(3):198-199.
4
Content of botulinum neurotoxin in Botox®/Vistabel®, Dysport®/Azzalure®, and Xeomin®/Bocouture®.保妥适(Botox®/Vistabel®)、丽舒妥(Dysport®/Azzalure®)和西马托(Xeomin®/Bocouture®)中肉毒神经毒素的含量。
Drugs R D. 2010;10(2):67-73. doi: 10.2165/11584780-000000000-00000.
5
Biological activity of two botulinum toxin type A complexes (Dysport and Botox) in volunteers: a double-blind, randomized, dose-ranging study.两种A型肉毒杆菌毒素复合物(Dysport和保妥适)在志愿者中的生物活性:一项双盲、随机、剂量范围研究。
J Neurol. 2008 Dec;255(12):1932-9. doi: 10.1007/s00415-008-0031-7. Epub 2008 Oct 7.
6
Botulinum neurotoxin detection and differentiation by mass spectrometry.通过质谱法检测和区分肉毒杆菌神经毒素
Emerg Infect Dis. 2005 Oct;11(10):1578-83. doi: 10.3201/eid1110.041279.
7
AAEM case report 16. Botulism. American Association of Electrodiagnostic Medicine.美国电诊断医学协会病例报告16. 肉毒中毒
Muscle Nerve. 2000 Jul;23(7):1137-44. doi: 10.1002/1097-4598(200007)23:7<1137::aid-mus21>3.0.co;2-7.
8
Historical aspects of botulinum toxin: Justinus Kerner (1786-1862) and the "sausage poison".肉毒杆菌毒素的历史渊源:贾斯蒂努斯·克纳(1786 - 1862)与“香肠毒素”
Neurology. 1999 Nov 10;53(8):1850-3. doi: 10.1212/wnl.53.8.1850.
9
Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.A型肉毒杆菌神经毒素中毒后运动终板的功能修复:神经芽与其母端之间突触活动的双相转换
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3200-5. doi: 10.1073/pnas.96.6.3200.
10
Botulinum toxin: historical perspective and potential new indications.肉毒杆菌毒素:历史回顾与潜在新适应症
Muscle Nerve Suppl. 1997;6:S129-45.

肉毒杆菌毒素注射的罕见并发症:一例报告

Rare Complication of Botox Injection: A Case Report.

作者信息

Rouientan Abdolreza, Alizadeh Otaghvar Hamidreza, Mahmoudvand Hossein, Tizmaghz Adnan

机构信息

Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran.

出版信息

World J Plast Surg. 2019 Jan;8(1):116-119. doi: 10.29252/wjps.8.1.116.

DOI:10.29252/wjps.8.1.116
PMID:30873373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6409137/
Abstract

Botulinum toxin (BTX) is also well-known as Botox is produced by a gram-positive anaerobic bacterium called Generally, clinical manifestations of BTX can be observed after consumption of contaminated food, from colonization of the infant gastrointestinal tract, as well as following the infection of the wound to this bacterium. There are seven types of this neurotoxin labeled as A, B, C (C1, C2), D, E, and F. Human botulinum is caused by types A, B, E and rarely F. The most common clinical symptoms of BTX in cosmetic goals are cervical dystonia, severe primary axillary hyperhidrosis, strabismus, neurogenic detrusor over-activity, chronic migraine, upper limb spasticity and blepharospasm. Botox has a wide range of therapeutic uses and occasionally patients receiving this treatment may experience botulism symptom including local and even distant and autonomic symptoms. Despite the efficacies of Botox in treatment of myriad neurologic and cosmetic conditions, it may carry some risk of sever adverse effects which may be the result of local or systemic spreading of the drug. Our patient was a 22 years old man who received Botox for axillary hyperhidrosis after two weeks, when most of generalized complications of botulinum toxin appeared. This case was introduced for being aware of dangerous complication of Botox. Pyridostigmine could relieve symptoms of the patient.

摘要

肉毒杆菌毒素(BTX),也被称为保妥适,由一种革兰氏阳性厌氧菌肉毒杆菌产生。一般来说,食用受污染食物、婴儿胃肠道定植该细菌以及伤口感染该细菌后,均可观察到BTX的临床表现。这种神经毒素有七种类型,分别标记为A、B、C(C1、C2)、D、E和F。人类肉毒中毒由A、B、E型以及罕见的F型引起。在美容领域,BTX最常见的临床症状是颈部肌张力障碍、严重原发性腋窝多汗症、斜视、神经源性逼尿肌过度活动、慢性偏头痛、上肢痉挛和眼睑痉挛。保妥适有广泛的治疗用途,偶尔接受这种治疗的患者可能会出现肉毒中毒症状,包括局部甚至远处及自主神经症状。尽管保妥适在治疗多种神经和美容疾病方面有效,但它可能存在一些严重不良反应的风险,这可能是药物局部或全身扩散的结果。我们的患者是一名22岁男性,在接受保妥适治疗腋窝多汗症两周后,出现了肉毒杆菌毒素的大多数全身性并发症。介绍该病例是为了让大家了解保妥适的危险并发症。新斯的明可以缓解患者的症状。