Qian Minyu, Shi Jianxin, Zhang Zhuoya, Bi Dezhao, Tan Cheng
Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Front Microbiol. 2024 Aug 5;15:1434521. doi: 10.3389/fmicb.2024.1434521. eCollection 2024.
Growing evidence indicates a potential association between the gut microbiome and psoriasis. Nevertheless, the precise nature of these associations and whether they constitute causal relationships remain unclear.
A rigorous bidirectional two-sample Mendelian randomization study was undertaken to establish a putative causal link between gut microbiota and psoriasis. We drew upon publicly available datasets containing summary statistics from GWAS to accomplish this. Utilizing various analytical techniques, including inverse variance weighting, MR-Egger, weighted median, weighted model, and MR-PRESSO, we sought to validate the putative causal association between gut microbiota and psoriasis. A reverse Mendelian randomization analysis was conducted to further investigate the relationship.
After conducting a forward Mendelian randomization analysis, a causal relationship was established between 19 gut microbiota and psoriasis. Furthermore, the reverse MR study revealed causality between psoriasis and 13 gut microbiota. Notably, no substantial heterogeneity of instrumental variables or horizontal pleiotropy was observed.
This research suggests a potential genetic association and causal nexus between gut microorganisms and psoriasis, indicating potential implications for the clinical management and therapy of psoriasis. Additional observational studies with a larger population sample size and animal model experiments are imperative to fully elucidate this association's underlying mechanisms.
越来越多的证据表明肠道微生物群与银屑病之间存在潜在关联。然而，这些关联的确切性质以及它们是否构成因果关系仍不清楚。
进行了一项严格的双向两样本孟德尔随机化研究，以建立肠道微生物群与银屑病之间的假定因果联系。我们利用包含全基因组关联研究（GWAS）汇总统计数据的公开可用数据集来完成此任务。使用各种分析技术，包括逆方差加权、MR-Egger、加权中位数、加权模型和MR-PRESSO，我们试图验证肠道微生物群与银屑病之间的假定因果关联。进行了反向孟德尔随机化分析以进一步研究这种关系。
在进行正向孟德尔随机化分析后，确定了19种肠道微生物群与银屑病之间的因果关系。此外，反向孟德尔随机化研究揭示了银屑病与13种肠道微生物群之间的因果关系。值得注意的是，未观察到工具变量的实质性异质性或水平多效性。
本研究表明肠道微生物与银屑病之间存在潜在的遗传关联和因果联系，这对银屑病的临床管理和治疗具有潜在意义。需要更多具有更大人群样本量的观察性研究和动物模型实验来充分阐明这种关联的潜在机制。
