Virtually any longstanding, recalcitrant inflammatory dermatosis may evolve into a cutaneous T-cell lymphoma. Although several entities within the parapsoriasis group can undergo malignant degeneration, most cases of cutaneous T-cell lymphoma are not preceded by parapsoriasis; a preceding inflammatory dermatosis that is not a parapsoriasis may be much more common. Among the parapsoriasis, lymphomatoid papulosis and large-plaque parapsoriasis and its variant, retiform parapsoriasis, have a variable tendency to undergo malignant degeneration. For any dermatosis deemed to have a significant premalignant potential, a plan of aggressive management with relatively non-aggressive modalities (for example, topical steroids, UVB light, and psoralen plus UVA light) should be considered.
实际上,几乎任何长期存在、顽固的炎性皮肤病都可能演变成皮肤T细胞淋巴瘤。虽然副银屑病组中的几个病种可能会发生恶性变,但大多数皮肤T细胞淋巴瘤病例之前并无副银屑病;一种并非副银屑病的先前炎性皮肤病可能更为常见。在副银屑病中,淋巴瘤样丘疹病、大斑块副银屑病及其变异型——网状副银屑病,具有不同程度的发生恶性变的倾向。对于任何被认为具有显著恶变潜能的皮肤病,应考虑采用相对温和的方式进行积极治疗(例如外用类固醇、窄谱中波紫外线光疗以及补骨脂素加紫外线A光疗)。