Pavlovskaia A I
Arkh Patol. 1983;45(10):64-8.
A case of sinus histiocytosis with massive lymphadenopathy in a boy of 13 with multiple subcutaneous tumor-like formations 0.5 to 2.5 cm in diameter is described. The general condition of the patient was not changed despite the 7-month course of the disease. Mild anemia and increased ESR were observed. Microscopically the formations presented massive "dense" infiltrates of lymphoid, plasma cells, and histiocytes-macrophages with foci of fibrosis and xanthomatosis. Since the morphological picture of sinus histiocytosis with massive lymphadenopathy may to some extent imitate the substrate of some tumor diseases of the hemopoietic and lymphoid tissues (malignant histiocytosis, histiocytosis X, lymphogranulomatosis, lymphosarcoma), their differential diagnosis is presented.
本文描述了一名13岁男孩患窦组织细胞增生症伴巨大淋巴结病，有多个直径0.5至2.5厘米的皮下肿瘤样肿物。尽管病程长达7个月，但患者的一般状况未发生改变。观察到轻度贫血和血沉加快。显微镜下，肿物呈现大量由淋巴细胞、浆细胞和组织细胞 - 巨噬细胞组成的“致密”浸润，并伴有纤维化和黄色瘤形成灶。由于窦组织细胞增生症伴巨大淋巴结病的形态学表现可能在一定程度上模仿造血和淋巴组织某些肿瘤性疾病（恶性组织细胞增生症、组织细胞增生症X、淋巴肉芽肿病、淋巴肉瘤）的病理特征，因此对它们进行了鉴别诊断。
