Li Wen-Wei, Zhang Jia-Xin, Wang Jia, Chen Ya-Qing, Lai Sha, Qiu Zhi-Kun
Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Front Neurol. 2024 Aug 5;15:1432966. doi: 10.3389/fneur.2024.1432966. eCollection 2024.
The question of whether a correlation exists between migraine and five psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), anorexia nervosa (AN), bipolar disorder (BIP), and schizophrenia (SCZ), remains a matter of controversy. Hence, this research aims to investigate whether there is a possible association between migraine and five psychiatric disorders.
We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to assess the causality between migraine and five psychiatric disorders. Genetic associations of PTSD, MDD, AN, BIP, and SCZ were obtained from the Psychiatric Genomics Consortium (PGC) database and genetic associations of migraine with aura and migraine without aura were obtained from the FinnGen dataset. We used the inverse-variance weighted (IVW), weighted median, weighted mode, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and MR Egger regression methods to evaluate the association of genetically predicted exposure with the risk of outcome.
MR demonstrated that MDD was associated with a high risk of migraine without aura (OR = 1.930578, 95% confidence interview (CI): 1.224510, 3.043550, < 0.05), but BIP was related to a low risk of migraine without aura (OR = 0.758650, 95%CI: 0.639601, 0.899858, < 0.05). According to the results of reverse MR, migraine with aura was associated with a high risk of BIP (OR = 1.019100, 95%CI: 1.002538, 1.035935, < 0.05), and migraine without aura was associated with an increased risk of AN (OR = 1.055634, 95%CI: 1.023859, 1.088394, < 0.05).
Our results provide evidence of the potential causal association between migraine and some psychiatric disorders. It may contribute to the prevention of migraine and some psychiatric disorders.
偏头痛与包括创伤后应激障碍（PTSD）、重度抑郁症（MDD）、神经性厌食症（AN）、双相情感障碍（BIP）和精神分裂症（SCZ）在内的五种精神障碍之间是否存在关联，仍是一个有争议的问题。因此，本研究旨在调查偏头痛与五种精神障碍之间是否可能存在关联。
我们进行了一项双向双样本孟德尔随机化（MR）分析，以评估偏头痛与五种精神障碍之间的因果关系。PTSD、MDD、AN、BIP和SCZ的基因关联数据来自精神基因组学联盟（PGC）数据库，有先兆偏头痛和无先兆偏头痛的基因关联数据来自芬兰基因数据集。我们使用逆方差加权（IVW）、加权中位数、加权众数、MR多效性残差和异常值（MR-PRESSO）以及MR埃格回归方法，来评估基因预测暴露与结局风险之间的关联。
MR分析表明，MDD与无先兆偏头痛的高风险相关（比值比[OR]=1.930578，95%置信区间[CI]：1.224510，3.043550，P<0.05），但BIP与无先兆偏头痛的低风险相关（OR=0.758650，95%CI：0.639601，0.899858，P<0.05）。根据反向MR的结果，有先兆偏头痛与BIP的高风险相关（OR=1.019100，95%CI：1.002538，1.035935，P<0.05），无先兆偏头痛与AN的风险增加相关（OR=1.055634，95%CI：1.023859，1.088394，P<0.05）。
我们的结果为偏头痛与某些精神障碍之间潜在的因果关联提供了证据。这可能有助于预防偏头痛和某些精神障碍。
