Nikbakhtzadeh Marjan, Bordbar Sanaz, Seyedi Samaneh, Ranjbaran Mina, Ashabi Ghorbangol, Kheradmand Afshin
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
Cent Nerv Syst Agents Med Chem. 2025;25(3):211-229. doi: 10.2174/0118715249302594240801171612.
Brain ischemia occurs following heart failure, thromboembolism, and atherosclerosis, and it is characterized by the disturbance of blood flow resulting from the blockage of blood vessels. After a series of studies, it is deduced that various changes occur following stroke, including neural death and changes in plasticity. Studies have reported that neurotransmitters tend to change following stroke. These changes that occur surrounding the infarct area following stroke can be considered new therapeutic targets for stroke rehabilitation. Although various studies have reported that different neurotransmitters have a promising role in either the progression or the rehabilitation following stroke, they have not found any pharmacological interventions to help the previous rehabilitation therapeutics. Phytocompounds also offer potential therapeutic benefits in stroke management due to their antioxidative and anti-inflammatory properties. This article aimed to compile recent advancements in neurotransmitter research related to ischemia and explore the potential use of neurotransmitter agonists/antagonists in ischemic conditions to identify potential drug candidates for treating the severe and prolonged stages of stroke in the future.
脑缺血发生在心力衰竭、血栓栓塞和动脉粥样硬化之后，其特征是血管阻塞导致血流紊乱。经过一系列研究推断，中风后会发生各种变化，包括神经死亡和可塑性变化。研究报告称，中风后神经递质往往会发生变化。中风后梗死区域周围发生的这些变化可被视为中风康复的新治疗靶点。尽管各种研究报告称，不同的神经递质在中风后的进展或康复中具有潜在作用，但尚未找到任何有助于先前康复治疗的药物干预措施。植物化合物因其抗氧化和抗炎特性，在中风管理中也具有潜在的治疗益处。本文旨在汇编与缺血相关的神经递质研究的最新进展，并探索神经递质激动剂/拮抗剂在缺血条件下的潜在用途，以确定未来治疗中风严重和长期阶段的潜在候选药物。
