Fassio G, Albizzati M G, Bassi S, Frattola L
J Int Med Res. 1979;7(6):492-501. doi: 10.1177/030006057900700603.
Twenty patients suffering from transient attacks of ischaemia were studied. Seven received acetylsalicylic acid, six dipyridamole and seven a combination of the two drugs. No significant difference in platelet aggregation was shown in the acute phase between the three treatment groups using an adenosine diphosphate test method. Using Thrombofax platelet substitute, however, a significant difference was seen in all measures. On the seventh day following the ischaemic attack the Thrombofax values returned to normal but, in contrast, Platelet Factor 4 release was increased. Monthly testing of platelet activity during treatment shows that the combination of acetylsalicylic acid with dipyridamole was more effective in bringing about an early inhibition of Platelet Factor 4 release than either agent alone.
对20名患有短暂性缺血发作的患者进行了研究。7名患者接受了阿司匹林治疗，6名患者接受了双嘧达莫治疗，7名患者接受了两种药物的联合治疗。使用二磷酸腺苷检测方法，在急性期三个治疗组之间未显示出血小板聚集有显著差异。然而，使用血栓传真血小板替代物时，在所有测量指标上都观察到了显著差异。缺血发作后第7天，血栓传真值恢复正常，但相比之下，血小板第4因子释放增加。治疗期间每月对血小板活性进行检测，结果显示，阿司匹林与双嘧达莫联合使用比单独使用任何一种药物都能更有效地早期抑制血小板第4因子释放。
