Synthesis of the Corrected Structure Assigned to Clonorosin B, an Alkaloid Obtained from the Soil-derived Fungus YRS-06.

The revised structure, , assigned to the title natural product has been prepared by chemical synthesis using a reaction sequence involving six simple steps starting from 2,3-dimethoxybenzaldehyde and proceeding via intermediates , , and . A comparison of the NMR data acquired on synthetically derived compound with those reported for the natural product reveals an excellent match. Preliminary biological screening of compound along with analogues/precursors , , , , , , and revealed that none exhibited antibacterial, antifungal or cytotoxic effects.