Han Yong-Ying, Yang Weiguang, Lan Ping, Khalil Zeinab G, Capon Robert J, Banwell Martin G
Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China.
Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
J Nat Prod. 2024 Sep 27;87(9):2310-2316. doi: 10.1021/acs.jnatprod.4c00777. Epub 2024 Aug 20.
The revised structure, , assigned to the title natural product has been prepared by chemical synthesis using a reaction sequence involving six simple steps starting from 2,3-dimethoxybenzaldehyde and proceeding via intermediates , , and . A comparison of the NMR data acquired on synthetically derived compound with those reported for the natural product reveals an excellent match. Preliminary biological screening of compound along with analogues/precursors , , , , , , and revealed that none exhibited antibacterial, antifungal or cytotoxic effects.
已通过化学合成制备了赋予标题天然产物的修订结构，使用从2,3 - 二甲氧基苯甲醛开始的包含六个简单步骤的反应序列，并经由中间体、和进行。对合成得到的化合物所获取的核磁共振数据与报道的天然产物的数据进行比较，结果显示匹配度极佳。对化合物以及类似物/前体、、、、、和进行的初步生物学筛选表明，它们均未表现出抗菌、抗真菌或细胞毒性作用。
