Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda-shi, Chiba 278-0022, Japan.
Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Kanagawa 230-0045, Japan.
Int Immunol. 2024 Oct 26;36(11):559-566. doi: 10.1093/intimm/dxae050.
Allergy is a complex array of diseases influenced by innate and adaptive immunity, genetic polymorphisms, and environmental triggers. Atopic dermatitis is a chronic inflammatory skin disease characterized by barrier defects and immune dysregulation, sometimes leading to asthma and food allergies because of the atopic march. During atopic skin inflammation, Langerhans cells and dendritic cells (DCs) in the skin capture and deliver allergen information to local lymph nodes. DCs are essential immune sensors coordinating immune reactions by capturing and presenting antigens to T cells. In the context of allergic responses, DCs play a crucial role in instructing two types of helper T cells-type 2 helper T (Th2) cells and follicular helper T (TFH) cells-in allergic responses and IgE antibody responses. In skin sensitization, the differentiation and function of Th2 cells and TFH cells are influenced by skin-derived factors, including epithelial cytokines, chemokines, and signalling pathways to modify the function of migratory DCs and conventional DCs. In this review, we aim to understand the specific mechanisms involving DCs in allergic responses to provide insights into the pathogenesis of allergic diseases and potential therapeutic strategies.
过敏是一种由先天和适应性免疫、遗传多态性和环境触发因素共同影响的复杂疾病。特应性皮炎是一种慢性炎症性皮肤病，其特征为屏障缺陷和免疫失调，有时会因特应性进程而导致哮喘和食物过敏。在特应性皮炎炎症过程中，皮肤中的朗格汉斯细胞和树突状细胞（DCs）捕获并向局部淋巴结传递过敏原信息。DCs 是至关重要的免疫传感器，通过捕获和呈递抗原来协调 T 细胞的免疫反应。在过敏反应中，DCs 在指导两种辅助性 T 细胞（Th2 细胞和滤泡辅助性 T 细胞（TFH）细胞）的分化和功能方面发挥着关键作用，从而促进过敏反应和 IgE 抗体反应。在皮肤致敏过程中，Th2 细胞和 TFH 细胞的分化和功能受到皮肤来源的因子的影响，包括上皮细胞因子、趋化因子和信号通路，以改变迁移性 DCs 和常规 DCs 的功能。在这篇综述中，我们旨在了解涉及 DCs 的过敏反应的特定机制，以深入了解过敏疾病的发病机制和潜在的治疗策略。
