T follicular helper and T2 cells in allergic responses.

IL-4 is a cytokine commonly secreted by T2 and follicular helper T (T) cells after antigenic sensitization. T2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by T2 and T cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting T cells, but not by T2 cells. In this review, we discuss the role of T2 and T cells in IgE production and allergic responses.