Jiang Yang-Yi, Jiang Xiao-Li, Yu Hai-Ning
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Nephrology Department, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398(1):261-278. doi: 10.1007/s00210-024-03373-4. Epub 2024 Aug 20.
Dysregulation of lipid metabolism plays a key role in the onset and progression of CKD, and a thorough understanding of its regulatory mechanisms is essential for the development of effective treatments. In recent years, an increasing number of studies have focused on the pharmacological activities of natural products and their application in the treatment of chronic diseases. Natural products, including plant extracts and bioactive compounds, have been shown to exert anti-inflammatory, antioxidant, antifibrosis, and anti-apoptotic effects through various signaling pathways in the treatment of CKD. Many natural products have been shown to target dysregulated lipid metabolism through various signaling pathways. This review summarizes the key regulatory factors and signaling pathways involved in the dysregulation of lipid metabolism in chronic kidney disease (CKD), highlighting their importance as potential therapeutic targets. Recently published research on the potential therapeutic benefits of natural products for the treatment of CKD was described. These studies have revealed the multi-target role of natural products in the regulation of lipid metabolism. Natural products show great potential in targeting lipid metabolism-related pathways, offering a novel research direction for the treatment of CKD while providing a scientific basis and experimental support for the development of new treatment strategies.
脂质代谢失调在慢性肾脏病（CKD）的发生和发展中起关键作用，深入了解其调控机制对于开发有效的治疗方法至关重要。近年来，越来越多的研究聚焦于天然产物的药理活性及其在慢性病治疗中的应用。天然产物，包括植物提取物和生物活性化合物，已被证明在CKD治疗中可通过多种信号通路发挥抗炎、抗氧化、抗纤维化和抗凋亡作用。许多天然产物已被证明可通过多种信号通路靶向脂质代谢失调。本综述总结了慢性肾脏病（CKD）中脂质代谢失调所涉及的关键调控因子和信号通路，强调了它们作为潜在治疗靶点的重要性。描述了最近发表的关于天然产物治疗CKD潜在益处的研究。这些研究揭示了天然产物在脂质代谢调控中的多靶点作用。天然产物在靶向脂质代谢相关通路方面显示出巨大潜力，为CKD治疗提供了新的研究方向，同时为新治疗策略的开发提供了科学依据和实验支持。
