Badran Aya Y, Abd Elazim Nagwa E, Yousef Azza Rady, Mekkawy Marwa M
Department of Dermatology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Dermatology, Venereology, and Andrology Department, Al-Qusiya Central Hospital, Ministry of Health, Assiut, Egypt .
Dermatol Surg. 2025 Jan 1;51(1):61-66. doi: 10.1097/DSS.0000000000004372. Epub 2024 Aug 20.
Periorbital hyperpigmentation (POH) is a therapeutic problem. Platelet-rich plasma (PRP) has been successfully used in some pigmentary disorders including POH. Proper evaluation of treatment in POH can be difficult.
To assess the efficacy and safety of PRP injections for POH in skin phototypes III and IV by multiple clinical tools.
A clinical trial included 30 patients with POH, skin phototypes III and IV. Three sessions of intradermal PRP injections were used in periorbital area every month. Treatment was assessed on different clinical levels 1 month after the last session by POH severity grading, blinded photographic assessment, and patient satisfaction. Adverse effects of PRP were evaluated.
A significant improvement in POH was documented by disease severity grading, patient satisfaction, and to a lesser extent by photographic evaluation. Grade II-POH showed the best improvement. More than half of the cases were satisfied and very satisfied. Lower disease grades, constitutional POH, and epidermal pigmentation showed significant improvement. Side effects were mostly tolerated.
The present results confirmed the beneficial role of PRP in improving POH. Multiple clinical tools are preferred for a more reliable assessment of treatment. Certain clinical types and grades of POH are suggested to respond more to PRP therapy.
眶周色素沉着（POH）是一个治疗难题。富含血小板血浆（PRP）已成功用于包括POH在内的一些色素沉着性疾病。对POH治疗进行恰当评估可能具有挑战性。
通过多种临床工具评估PRP注射治疗皮肤光型III和IV型POH的疗效和安全性。
一项临床试验纳入了30例皮肤光型III和IV型的POH患者。每月在眶周区域进行3次皮内PRP注射。在最后一次注射后1个月，通过POH严重程度分级、盲法摄影评估和患者满意度在不同临床层面评估治疗效果。评估PRP的不良反应。
通过疾病严重程度分级、患者满意度以及在较小程度上通过摄影评估记录到POH有显著改善。II级POH改善最为明显。超过半数的病例表示满意或非常满意。疾病分级较低、先天性POH和表皮色素沉着有显著改善。副作用大多可耐受。
目前的结果证实了PRP在改善POH方面的有益作用。为了更可靠地评估治疗效果，首选多种临床工具。提示某些临床类型和分级的POH对PRP治疗反应更佳。
