Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Histology and cell biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
J Cosmet Dermatol. 2022 Oct;21(10):4332-4338. doi: 10.1111/jocd.15051. Epub 2022 Aug 1.
Periorbital hyperpigmentation is a recurrent problem in dermatologic clinics that affect the patients' quality of life and their psychological status. Platelet-rich plasma (PRP) may serve as a source of different growth factors which may reduce the pigmentation in this problem. Carboxytherapy is carbon dioxide infusion into human tissue for therapeutic purposes.
To evaluate and compare the clinical efficacy of PRP and carboxytherapy in the treatment of periorbital dark circles (PODC). Histopathological evaluation was also done.
Split-face study of 23 patients with PODC treated with PRP at the right side and carboxytherapy at the left side. Patients received four sessions; one session/week. Final follow-up evaluation was done 3 months after the last session by clinical and histopathological assessment.
PRP showed significant better response (p = 0.002), shorter downtime, and tolerable side effects than caboxytherapy. Reduction in area percent of melanin after PRP injections showed 46.6% improvement, while after carboxytherapy, it showed only 14.3% improvement.
The present study showed that PRP is more effective and tolerable than caboxytherapy in the treatment of PODC.
眶周色素沉着是皮肤科诊所中经常出现的问题，会影响患者的生活质量和心理健康。富血小板血浆（PRP）可以作为多种生长因子的来源，这些生长因子可能会减轻该问题的色素沉着。二氧化碳疗法是将二氧化碳注入人体组织以达到治疗目的。
评估和比较 PRP 和二氧化碳疗法治疗眶周黑眼圈（PODC）的临床疗效。还进行了组织病理学评估。
对 23 名 PODC 患者进行了一项双侧治疗的分割面研究，右侧接受 PRP 治疗，左侧接受二氧化碳疗法治疗。患者每周接受一次治疗，共进行四次。末次治疗后 3 个月进行最终随访评估，通过临床和组织病理学评估。
PRP 显示出显著更好的疗效（p=0.002）、更短的恢复期和可耐受的副作用，优于二氧化碳疗法。PRP 注射后黑素面积百分比减少了 46.6%，而二氧化碳疗法后仅减少了 14.3%。
本研究表明，PRP 在治疗 PODC 方面比二氧化碳疗法更有效且更耐受。
