Ellabban Noura F, Eyada Moustafa, Nada Hesham, Kamel Noha
Dermatology & Andrology Department, Ministry of Health, Mansoura, Egypt.
Dermatology, Andrology & STDs Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
J Cosmet Dermatol. 2019 Dec;18(6):1680-1685. doi: 10.1111/jocd.12964. Epub 2019 Apr 25.
Various therapeutic modalities for periorbital hyperpigmentation (POH) have been proposed.
This study was designed to compare the efficacy and tolerability of autologous platelet-rich plasma (PRP) and chemical peeling in POH.
Forty-two patients were enrolled in this study and randomly subdivided into two groups. Group A patients were assigned to receive four sessions of chemical peeling using trichloroacetic acid and lactic acid, while group B was assigned to patients who received four sessions of PRP injection with 2 weeks of intervals. Patients were assessed by digital photographs. The degree of improvement included four degrees from poor to excellent, and side effects were reported.
Females constituted 38 out of 42 patients (mean age, 28.14 ± 3.47 years). There was a significant improvement in favor of chemical peeling over PRP. Good improvement occurred in 47.6% in the group A versus 4.8% in group B (P < 0.001). None of the PRP group had excellent improvement, while 38% of chemical peeling group did. Most of group A patients reported very pleased (47.6%) to excellent (38%) degree, in contrast to group B where 52.5% were just pleased (P < 0.001). Some of group A patients experienced itching (14.3%) and redness (14.3%), while in group B, they experienced pain (23.8%) and edema (14.3%) with nonsignificant difference between both groups (P = 0.07).
Both PRP and chemical peeling are effective for treatment of POH; however, chemical peeling is much more effective, tolerable, and satisfying procedure than PRP.
针对眶周色素沉着（POH）已提出了多种治疗方式。
本研究旨在比较自体富血小板血浆（PRP）和化学剥脱术治疗POH的疗效和耐受性。
42例患者纳入本研究并随机分为两组。A组患者接受4次使用三氯乙酸和乳酸的化学剥脱术，而B组患者接受4次间隔2周的PRP注射。通过数码照片对患者进行评估。改善程度分为从差到优4个等级，并报告了副作用。
42例患者中有38例为女性（平均年龄，28.14±3.47岁）。与PRP相比，化学剥脱术有显著更好的改善效果。A组有47.6%改善良好，而B组为4.8%（P<0.001）。PRP组无一例改善优异，而化学剥脱术组有38%改善优异。A组大多数患者报告非常满意（47.6%）至优异（38%），相比之下B组有52.5%只是满意（P<0.001）。A组部分患者出现瘙痒（14.3%）和发红（14.3%），而B组患者出现疼痛（23.8%）和水肿（14.3%），两组之间差异无统计学意义（P=0.07）。
PRP和化学剥脱术治疗POH均有效；然而，化学剥脱术比PRP更有效、更耐受且更令人满意。
