Duke Regeneration Center and Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Institute of Molecular Biotechnology (IMBA), Austrian Academy of Sciences, Vienna Biocenter (VBC), 1030 Vienna, Austria.
Cell Stem Cell. 2024 Sep 5;31(9):1244-1261. doi: 10.1016/j.stem.2024.07.007. Epub 2024 Aug 19.
Regeneration is a heroic biological process that restores tissue architecture and function in the face of day-to-day cell loss or the aftershock of injury. Capacities and mechanisms for regeneration can vary widely among species, organs, and injury contexts. Here, we describe "hallmarks" of regeneration found in diverse settings of the animal kingdom, including activation of a cell source, initiation of regenerative programs in the source, interplay with supporting cell types, and control of tissue size and function. We discuss these hallmarks with an eye toward major challenges and applications of regenerative biology.
再生是一种英勇的生物学过程，它可以在面对日常的细胞损失或损伤余波时，恢复组织的结构和功能。不同物种、器官和损伤环境中的再生能力和机制可能有很大差异。在这里，我们描述了在动物王国的各种环境中发现的再生特征，包括细胞来源的激活、来源中再生程序的启动、与支持细胞类型的相互作用以及组织大小和功能的控制。我们讨论了这些特征，着眼于再生生物学的主要挑战和应用。
