Duke Regeneration Center, Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Development. 2023 Dec 1;150(23). doi: 10.1242/dev.202166. Epub 2023 Nov 27.
Tissue regeneration is not simply a local repair event occurring in isolation from the distant, uninjured parts of the body. Rather, evidence indicates that regeneration is a whole-animal process involving coordinated interactions between different organ systems. Here, we review recent studies that reveal how remote uninjured tissues and organ systems respond to and engage in regeneration. We also discuss the need for toolkits and technological advancements to uncover and dissect organ communication during regeneration.
组织再生不仅仅是一个局部修复事件，它与身体远处的未受伤部分是相互隔离的。相反，有证据表明再生是一个整体动物的过程，涉及不同器官系统之间的协调相互作用。在这里，我们回顾了最近的研究，这些研究揭示了远程未受伤组织和器官系统如何对再生做出反应并参与其中。我们还讨论了需要工具包和技术进步来揭示和剖析再生过程中的器官通讯。
