Schutte Rudolph, Zhang Jufen, Kiran Mahreen, Ball Graham
School of Allied Health, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK.
Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, UK.
Alcohol Clin Exp Res (Hoboken). 2024 Oct;48(10):1915-1922. doi: 10.1111/acer.15426. Epub 2024 Aug 20.
The association between arterial stiffness and alcohol consumption is still controversial. We investigated this relationship by performing continuous analysis in men drinking only beer/cider, and women drinking only red wine.
This cross-sectional study involved participants aged 40-69 years consisting of 9029 men who drank only beer/cider, and 6989 women drinking only red wine. Alcohol consumption was captured by self-reported questionnaire and reported as units per week, where one unit is equal 10 mL pure ethanol. Arterial stiffness index (ASI) was estimated using photoplethysmography.
In men consuming a mean 17.8 (5th and 95th percentiles, 2.6-76.7) units/week, ASI increased by heptiles (sevenths) of alcohol captured from beer/cider consumption and after adjusting for age (9.14, 9.40, 9.51, 9.53, 9.80, 9.80, 10.00 m/s; p-trend < 0.001) and after full adjustment (9.29, 9.46. 9.55, 9.55, 9.73, 9.73, 9.75 m/s; p-trend = 0.013). Similarly, in women consuming a mean 8.1 (1.6-29.3) units/week, ASI increased by heptiles of alcohol captured from red wine consumption and after adjusting for age (8.05, 8.05, 8.05, 8.11, 8.17, 8.30, 8.45 m/s; p-trend = 0.012) and borderline significant after full adjustment (8.05, 8.07, 8.05, 8.07, 8.11, 8.22, 8.43 m/s; p-trend = 0.055). These associations were confirmed in multivariable-adjusted regression analysis in all men, men younger and older than 50 years, and when consuming more than 14 units per week. Similarly, these associations were confirmed in all women, women older than 50 years, and in those consuming more than 14 units per week.
Positive linear relationships exist between arterial stiffness and alcohol, irrespective of whether captured from beer/cider consumption in men or red wine consumption in women. No evidence existed to support the notion that our arteries benefit from any level of alcohol consumption.
动脉僵硬度与饮酒之间的关联仍存在争议。我们通过对只饮用啤酒/苹果酒的男性和只饮用红酒的女性进行连续分析来研究这种关系。
这项横断面研究纳入了40 - 69岁的参与者，其中包括9029名只饮用啤酒/苹果酒的男性和6989名只饮用红酒的女性。饮酒量通过自我报告问卷获取，并以每周的单位数表示，其中一个单位等于10毫升纯乙醇。使用光电容积描记法估计动脉僵硬度指数（ASI）。
在平均每周饮用17.8（第5和第95百分位数，2.6 - 76.7）个单位的男性中，ASI随着从啤酒/苹果酒摄入的酒精量的七分之一增加而升高，在调整年龄后（9.14、9.40、9.51、9.53、9.80、9.80、10.00米/秒；p趋势<0.001）以及在完全调整后（9.29、9.46、9.55、9.55、9.73、9.73、9.75米/秒；p趋势 = 0.013）。同样，在平均每周饮用8.1（1.6 - 29.3）个单位的女性中，ASI随着从红酒摄入的酒精量的七分之一增加而升高，在调整年龄后（8.05、8.05、8.05、8.11、8.17、8.30、8.45米/秒；p趋势 = 0.012），在完全调整后接近显著（8.05、8.07、8.05、8.07、8.11、8.22、8.43米/秒；p趋势 = 0.055）。这些关联在所有男性、50岁及以上和50岁以下的男性以及每周饮酒超过14个单位的男性的多变量调整回归分析中得到证实。同样，这些关联在所有女性、50岁及以上的女性以及每周饮酒超过14个单位的女性中得到证实。
动脉僵硬度与酒精之间存在正线性关系，无论酒精是从男性饮用的啤酒/苹果酒中获取还是从女性饮用的红酒中获取。没有证据支持我们的动脉能从任何水平的饮酒中获益这一观点。
