Jepson R G, Fowkes F G, Donnan P T, Housley E
Wolfson Unit for the Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Edinburgh University, Scotland, UK.
Eur J Epidemiol. 1995 Feb;11(1):9-14. doi: 10.1007/BF01719940.
The aim of this study was to determine the relationship between alcohol consumption and occurrence of peripheral arterial disease in the general population. During 1988 in a cross sectional survey, the Edinburgh Artery Study, 1,592 men and women aged 55-74 years were selected at random from the age-sex registers of ten general practices distributed geographically and socio-economically across the city. participants were asked to recall the number of units of wine, beer and spirits consumed in the previous week and whether or not this was typical. Peripheral arterial disease was measured using the ankle brachial pressure index (ABPI). Men and women were analysed separately because of large differences in alcohol consumption. There was no association between ABPI and alcohol consumption in women but, in men, increasing alcohol consumption was associated with a higher ABPI (test for trend, p = 0.03) indicating less severe disease. This relationship was linear rather than U-shaped. In multiple regression analysis, after age-adjustment the ABPI was related to wine consumption but not beer or spirits in men (p < or = 0.01). On adjusting for age and cumulative lifetime cigarette smoking, the association of wine consumption with the ABPI was diminished but remained statistically significant (p < 0.05). On adjusting for age and social class, the relationship of total alcohol intake and wine consumption with the ABPI became non significant (p > 0.05). We conclude that in males, greater alcohol consumption is related to a higher ABPI and that any protective 'effect' of alcohol relates to wine consumption rather than beer or spirits.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是确定一般人群中饮酒与外周动脉疾病发生之间的关系。1988年在一项横断面调查——爱丁堡动脉研究中，从全市十个按地理位置和社会经济分布的普通诊所的年龄-性别登记册中随机选取了1592名55至74岁的男性和女性。参与者被要求回忆前一周饮用的葡萄酒、啤酒和烈酒的单位数量以及这是否为其通常的饮酒量。使用踝臂压力指数（ABPI）来测量外周动脉疾病。由于饮酒量存在巨大差异，对男性和女性分别进行了分析。女性的ABPI与饮酒量之间没有关联，但在男性中，饮酒量增加与较高的ABPI相关（趋势检验，p = 0.03），表明疾病不太严重。这种关系是线性的而非U形。在多元回归分析中，年龄调整后，男性的ABPI与葡萄酒消费量有关，而与啤酒或烈酒消费量无关（p≤0.01）。在对年龄和累积终身吸烟量进行调整后，葡萄酒消费与ABPI的关联减弱，但仍具有统计学意义（p < 0.05）。在对年龄和社会阶层进行调整后，总酒精摄入量和葡萄酒消费与ABPI的关系变得不显著（p > 0.05）。我们得出结论，在男性中，饮酒量增加与较高的ABPI相关，并且酒精的任何保护“作用”与葡萄酒消费有关，而非啤酒或烈酒。（摘要截选至250词）
