Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, South Korea.
Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, South Korea; Department of Materials Science and Engineering, Institute of Engineering Research, BioMAX, Soft Foundry Institute, Seoul National University, Seoul, South Korea.
Trends Immunol. 2024 Sep;45(9):705-714. doi: 10.1016/j.it.2024.07.009. Epub 2024 Aug 19.
The extracellular matrix (ECM) of solid tumors impacts the antitumor activities of CD8 T and natural killer (NK) cells in a variety of ways. Cell motility is restricted by the tumor ECM which creates physical barriers. The tumor ECM directly alter the phenotypes and functions of cytotoxic lymphocytes, and indirectly influences immunological synapse-mediated interactions between cytotoxic lymphocytes and cancer cells. Therefore, strategies to improve solid tumor immunotherapy should be established by considering complex ternary interactions between cytotoxic lymphocytes, cancer cells, and the tumor ECM. Novel bioengineering tools approximating key characteristics of the tumor ECM, such as in vitro reconstituted 3D ECMs and microfluidics are valuable from a fundamental study viewpoint and from a translational perspective, aiming to enable systematic screening approaches.
肿瘤细胞外基质（ECM）以多种方式影响 CD8 T 细胞和自然杀伤（NK）细胞的抗肿瘤活性。细胞迁移受到肿瘤 ECM 的限制，它形成物理屏障。肿瘤 ECM 直接改变细胞毒性淋巴细胞的表型和功能，并间接影响细胞毒性淋巴细胞与癌细胞之间免疫突触介导的相互作用。因此，应该通过考虑细胞毒性淋巴细胞、癌细胞和肿瘤 ECM 之间的复杂三元相互作用来制定改善实体瘤免疫治疗的策略。模拟肿瘤 ECM 关键特征的新型生物工程工具，如体外重建的 3D ECM 和微流控技术，从基础研究的角度和转化的角度来看都是有价值的，旨在实现系统的筛选方法。
