Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Injury. 2024 Nov;55 Suppl 6:111823. doi: 10.1016/j.injury.2024.111823. Epub 2024 Aug 13.
Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing "omics" technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.
骨折相关感染是术后严重的并发症，给患者带来沉重的负担和额外的医疗费用。尽管这些感染对预后有重大影响，但由于目前可用的检测方法缺乏可接受的诊断参数，早期诊断仍然具有挑战性。这篇综述汇集了目前评估为早期诊断工具的基于血液的生物标志物的相关信息，并强调了其可靠性方面的挑战。为了克服这些挑战，近年来，利用“组学”技术和新型分析方法来发现生物标志物的新途径正在被研究。尽管这些方法很复杂，但它们似乎是骨折相关感染诊断中生物标志物发现的未来方向。
