Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361000, China.
Chen Hongduo Academician Workstation, Shaoxing Central Hospital, Shaoxing, China.
Sci Rep. 2024 Aug 20;14(1):19292. doi: 10.1038/s41598-024-69053-8.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a disease that causes an abnormal accumulation of fat in the liver, triggering inflammation and fibrosis, the mechanism of which is not fully understood and for which there is a lack of specific drug therapy. Far-infrared radiation (FIR) has demonstrated evident therapeutic efficacy across various diseases, and novel nanomaterial graphene patches can emit it through electric heating. This study aimed to investigate the potential protective effects of FIR against MAFLD. Mice were fed with a MCD diet to mimic MAFLD progression, and histopathology analysis, biochemical analysis, RT-qPCR, and Western blotting analysis were performed to assess the effect of FIR on MAFLD in vivo. The effect of FIR treatment on MAFLD in vitro was investigated by biochemical analysis and gene expression profiling of hepatocytes. Mice subjected to the MCD diet and treated with FIR exhibited reduced hepatic lipid deposition, inflammation, fibrosis and liver damage. The therapeutic effect exerted by FIR in mice may be caused by the enhancement of AMPK phosphorylation and inhibition of the TGFβ1-SMAD2/3 pathway. Besides, FIR intervention alleviated MAFLD in hepatocytes in vitro and the results were verified by gene expression profiling. Our results revealed a promising potential of FIR as a novel therapeutic approach for MAFLD.
代谢相关脂肪性肝病（MAFLD）是一种导致肝脏脂肪异常堆积，引发炎症和纤维化的疾病，其发病机制尚未完全阐明，且缺乏特异性药物治疗。远红外辐射（FIR）在多种疾病中表现出明显的治疗效果，而新型纳米材料石墨烯贴片可以通过电热产生它。本研究旨在探讨 FIR 对 MAFLD 的潜在保护作用。通过给予 MCD 饮食来模拟 MAFLD 的进展，对小鼠进行组织病理学分析、生化分析、RT-qPCR 和 Western blot 分析，以评估 FIR 对体内 MAFLD 的影响。通过生化分析和肝细胞基因表达谱分析研究了 FIR 治疗对 MAFLD 的体外作用。接受 MCD 饮食和 FIR 治疗的小鼠肝脏脂质沉积、炎症、纤维化和肝损伤减少。FIR 在小鼠中发挥的治疗作用可能是通过增强 AMPK 磷酸化和抑制 TGFβ1-SMAD2/3 通路引起的。此外，FIR 干预减轻了体外 MAFLD ，并且通过基因表达谱得到了验证。我们的研究结果揭示了 FIR 作为 MAFLD 新型治疗方法的潜在应用前景。
