Nowacka Agnieszka, Śniegocki Maciej, Smuczyński Wojciech, Ziółkowska Ewa
Department of Neurosurgery, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.
Department of Physiotherapy, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Techników 3, 85-801 Bydgoszcz, Poland.
Int J Mol Sci. 2025 May 27;26(11):5134. doi: 10.3390/ijms26115134.
Infrared and related light therapies are gaining increasing interest due to their potential therapeutic properties in treating various health conditions, particularly metabolic diseases such as insulin resistance and type 2 diabetes. These diseases often coexist with dyslipidemia, obesity, non-alcoholic fatty liver disease, and cardiovascular complications. This review paper analyzes the impact, primarily of far-infrared light therapy (FIR), on improving endothelial function, reducing oxidative stress, and modulating inflammatory responses-key factors in metabolic diseases. Preliminary studies suggest that FIR may improve blood circulation, increase the secretion of VEGF, and enhance insulin sensitivity by alleviating inflammatory states and oxidative damage commonly associated with these diseases. In addition, FIR has been associated with potential benefits in blood pressure regulation and lipid metabolism, which could contribute to reduced cardiovascular risk. However, it is important to acknowledge that most current evidence is derived from preclinical models and small-scale clinical trials, limiting direct applicability to broader patient populations. Moreover, significant variability exists in exposure parameters and treatment protocols across studies. While FIR therapy holds potential as a complementary approach to the conventional management of metabolic diseases, careful monitoring is essential to mitigate potential adverse effects. Further well-designed, large-scale clinical trials are necessary to validate the therapeutic efficacy, optimize treatment parameters, and comprehensively assess the safety profile of FIR interventions in metabolic health.
红外线及相关光疗法因其在治疗各种健康状况，特别是胰岛素抵抗和2型糖尿病等代谢性疾病方面的潜在治疗特性而越来越受到关注。这些疾病常与血脂异常、肥胖、非酒精性脂肪性肝病和心血管并发症并存。本综述文章分析了主要是远红外光疗法（FIR）对改善内皮功能、减轻氧化应激和调节炎症反应（代谢性疾病的关键因素）的影响。初步研究表明，FIR可能通过减轻通常与这些疾病相关的炎症状态和氧化损伤来改善血液循环、增加血管内皮生长因子（VEGF）的分泌并增强胰岛素敏感性。此外，FIR与血压调节和脂质代谢方面的潜在益处有关，这可能有助于降低心血管风险。然而，必须认识到，目前的大多数证据来自临床前模型和小规模临床试验，限制了其对更广泛患者群体的直接适用性。此外，各研究的暴露参数和治疗方案存在很大差异。虽然FIR疗法作为代谢性疾病传统管理的一种补充方法具有潜力，但仔细监测对于减轻潜在不良反应至关重要。需要进一步设计良好的大规模临床试验来验证治疗效果、优化治疗参数并全面评估FIR干预措施在代谢健康方面的安全性。
