Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand.
Phayao Hospital, Ministry of Public Health, Phayao, Thailand.
BMC Pediatr. 2024 Aug 20;24(1):531. doi: 10.1186/s12887-024-05010-8.
Health-related quality of life (HRQOL) is a vital assessment to demonstrate the achievement in pediatric cancer care parallels that of medical treatment. The Pediatric Quality of Life Inventory (PedsQL) 3.0 Cancer Module in the Thai Version has become a standard tool to access the HRQOL among Thai children with cancer and their families. This study aimed to explore the HRQOL and factors related to HRQOL among pediatric oncology patients using the PedsQL 3.0 Cancer Module.
In 2018-2019, a single-institution, cross-sectional study was conducted among children with cancer and their families in Bangkok, Thailand. A paired-sample t-test was performed to evaluate the differences between the HRQOL scores of the child and parents' reports. Linear regression was used to evaluate factors associated with HRQOL and which particular domains of the PedsQL 3.0 Cancer Module were influenced.
Eighty-five children with cancer and their families were enrolled. The patients' mean age was 10.82 ± 5.48 years. The most common cancer types included acute lymphoblastic leukemia (n = 32, 67%), central nervous system tumors (n = 13, 15%), osteosarcoma (n = 10, 27%) and neuroblastoma (n = 9, 24%), in rank. The mean HRQOL scores in child and parent reports were 74.37 ± 15.7 and 70.42 ± 17.15, respectively (p = 0.034). Factors negatively correlated to HRQOL in parent reports were the number of outpatient visits (p = 0.019) and hospital admissions (p = 0.002). The number of hospitalizations was the only independent factor that affected HRQOL (p = 0.044). The number of outpatient visits and/or hospital admissions was influenced by pain and hurt, nausea, procedural anxiety and communication domains (p < 0.05). Only the number of hospitalizations was an independent factor influencing the procedural anxiety domain in HRQOL (p = 0.005).
HRQOL among Thai children with cancer was desirable from both children's and parent's perspectives. Differences between child and parent HRQOL scores were observed. The number of outpatient visits and hospital admissions affected HRQOL, particularly in the procedural anxiety aspect.
Thai Clinical Trials Registry (TCTR) Number: TCTR20200904001 (04/09/2020), https://www.thaiclinicaltrials.org/ .
健康相关生活质量（HRQOL）是展示儿科癌症护理成就的重要评估指标，与医疗同等重要。泰文版儿科生存质量问卷（PedsQL）3.0 癌症模块已成为评估泰国癌症儿童及其家庭 HRQOL 的标准工具。本研究旨在使用 PedsQL 3.0 癌症模块探讨儿科肿瘤患者的 HRQOL 及其相关因素。
2018-2019 年，在泰国曼谷的一家机构进行了一项单中心、横断面研究，对癌症患儿及其家庭进行了研究。采用配对样本 t 检验评估儿童和父母报告的 HRQOL 评分之间的差异。线性回归用于评估与 HRQOL 相关的因素，以及 PedsQL 3.0 癌症模块的哪些特定领域受到影响。
共纳入 85 名癌症患儿及其家庭。患儿的平均年龄为 10.82±5.48 岁。最常见的癌症类型包括急性淋巴细胞白血病（n=32，67%）、中枢神经系统肿瘤（n=13，15%）、骨肉瘤（n=10，27%）和神经母细胞瘤（n=9，24%）。儿童和父母报告的 HRQOL 平均得分分别为 74.37±15.7 和 70.42±17.15（p=0.034）。与父母报告的 HRQOL 呈负相关的因素是门诊就诊次数（p=0.019）和住院次数（p=0.002）。住院次数是唯一影响 HRQOL 的独立因素（p=0.044）。门诊就诊次数和/或住院次数影响疼痛和伤害、恶心、操作焦虑和沟通领域（p<0.05）。只有住院次数是影响 HRQOL 操作焦虑领域的独立因素（p=0.005）。
泰国癌症儿童的 HRQOL 从儿童和家长的角度来看都是理想的。儿童和家长 HRQOL 评分之间存在差异。门诊就诊次数和住院次数影响 HRQOL，特别是在操作焦虑方面。
泰国临床试验注册中心（TCTR）编号：TCTR20200904001（2020 年 9 月 4 日），https://www.thaiclinicaltrials.org/。
