Topraklik Oral and Dental Health Center, Ankara, Turkey.
Faculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey.
BMC Oral Health. 2024 Aug 20;24(1):964. doi: 10.1186/s12903-024-04749-x.
This study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease. It examines the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in gingival crevicular fluid (GCF) and saliva.
Forty Behçet's patients with gingivitis or periodontitis and 47 patients with either gingivitis or periodontitis but without BD were studied. Periodontal status was recorded with standard clinical indexes. GCF and saliva samples were obtained. NO, IL-1β and TNF-α levels were analysed. Current Behçet's symptoms and medications usage were recorded.
Mean salivary IL-1β was elevated (p = .045), and mean NO level was decreased in BD patients with gingivitis compared to patients without BD (p = .000). In contrast, mean NO level in crevicular fluid was higher in Behçet's patients with periodontitis than in patients without BD (p = .009). Furthermore, among Behçet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement (p = .000).
Based on our findings, the elevated levels of IL-1β in the saliva of Behçet's patients with gingivitis, along with the decreased NO level, indicate an altered inflammatory response in the oral cavity.
本研究探讨了贝赫切特病（BD）与牙周病之间的关系。BD 的特征为持续性口腔和生殖器溃疡以及虹膜炎，并研究了龈沟液（GCF）和唾液中的肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和一氧化氮（NO）水平。
研究纳入了 40 名患有牙龈炎或牙周炎的贝赫切特病患者和 47 名患有牙龈炎或牙周炎但无 BD 的患者。使用标准临床指标记录牙周状况。采集 GCF 和唾液样本。分析 NO、IL-1β 和 TNF-α 水平。记录当前贝赫切特病症状和药物使用情况。
与无 BD 的患者相比，患有牙龈炎的 BD 患者的唾液中 IL-1β 水平升高（p=0.045），NO 水平降低（p=0.000）。相比之下，患有牙周炎的 BD 患者的龈沟液中 NO 水平高于无 BD 的患者（p=0.009）。此外，在贝赫切特病患者中，有血管受累的患者的唾液 NO 水平低于无血管受累的患者（p=0.000）。
根据我们的发现，患有牙龈炎的贝赫切特病患者唾液中 IL-1β 水平升高，NO 水平降低，表明口腔内炎症反应发生改变。
