State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Suzhou, China.
Diabetes Obes Metab. 2024 Nov;26(11):5126-5137. doi: 10.1111/dom.15854. Epub 2024 Aug 20.
To assess the association of Life's Essential 8 (LE8) and the presence of abdominal aortic calcification (AAC) with mortality among middle-aged and older individuals.
Participants aged older than 40 years were enrolled from the National Health and Nutrition Examination Survey 2013-2014. AAC was assessed using dual-energy X-ray absorptiometry. Mortality data were ascertained through linkage with the National Death Index until 31 December 2019. The LE8 score incorporates eight components: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose and blood pressure. The total LE8 score, an unweighted average of all components, was categorized into low (0-49), medium (50-79) and high (80-100) scores.
This study included 2567 individuals, with a mean LE8 score of 67.28 ± 0.48 and an AAC prevalence of 28.28%. Participants with low LE8 scores showed a significantly higher prevalence of AAC (odds ratio = 2.12 [1.12-4.19]) compared with those with high LE8 scores. Over a median 6-year follow-up, there were 222 all-cause deaths, and 55 cardiovascular deaths occurred. Participants with AAC had an increased risk of all-cause (hazard ratio [HR] = 2.17 [1.60-2.95]) and cardiovascular (HR = 2.35 [1.40-3.93]) mortality. Moreover, individuals with AAC and low or medium LE8 scores exhibited a 137% (HR = 2.37 [1.58-3.54]) and 119% (HR = 2.19 [1.61-2.99]) higher risk of all-cause mortality, as well as a 224% (HR = 3.24 [1.73-6.04]) and 125% (HR = 2.25 [1.24-4.09]) increased risk of cardiovascular mortality, respectively.
The LE8 score correlates with AAC prevalence in middle-aged and older individuals and serves as a valuable tool for evaluating the risk of all-cause and cardiovascular mortality in individuals with AAC.
评估生命的 8 要素（LE8）与腹主动脉钙化（AAC）的存在与中老年个体死亡率之间的关系。
本研究纳入了 2013-2014 年全国健康与营养调查中年龄大于 40 岁的参与者。使用双能 X 射线吸收法评估 AAC。通过与国家死亡索引链接，确定截至 2019 年 12 月 31 日的死亡率数据。LE8 评分包含 8 个组成部分：饮食、身体活动、尼古丁暴露、睡眠健康、体重指数、血脂、血糖和血压。LE8 的总评分是所有组成部分的未加权平均值，分为低（0-49）、中（50-79）和高（80-100）。
本研究共纳入 2567 名参与者，平均 LE8 评分为 67.28±0.48，AAC 患病率为 28.28%。与 LE8 评分高的参与者相比，LE8 评分低的参与者 AAC 的患病率明显更高（比值比=2.12[1.12-4.19]）。在中位 6 年的随访期间，共发生 222 例全因死亡，55 例心血管死亡。AAC 患者的全因死亡风险（风险比[HR]=2.17[1.60-2.95]）和心血管死亡风险（HR=2.35[1.40-3.93]）均升高。此外，AAC 合并低或中 LE8 评分的患者全因死亡风险分别升高 137%（HR=2.37[1.58-3.54]）和 119%（HR=2.19[1.61-2.99]），心血管死亡风险分别升高 224%（HR=3.24[1.73-6.04]）和 125%（HR=2.25[1.24-4.09]）。
LE8 评分与中老年人群的 AAC 患病率相关，是评估 AAC 患者全因和心血管死亡风险的有用工具。
