Department of Neurosurgery, the 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.
Department of Neurosurgery, Peking University People's Hospital, Peking University, No.11 Xizhimen South Street, Beijing, 100044, China.
Sci Rep. 2024 Aug 26;14(1):19773. doi: 10.1038/s41598-024-70112-3.
The American Heart Association (AHA) recently redefined cardiovascular health (CVH) with the introduction of Life's Essential 8 (LE8), which encompasses eight areas (diet, physical activity, nicotine exposure, sleep duration body mass index, non-HDL cholesterol, blood glucose, and blood pressure). This study aimed to explore the relationships between both the aggregate and individual CVH metrics, as defined by Life's Essential 8, and cognitive function in older adults in the United States. This cross-sectional, population-based study analyzed data from the National Health and Nutrition Examination Survey conducted between 2011 and 2014, focusing on individuals aged 60 years and older. CVH was categorized as low (0-49), moderate (50-79), or high (80-100). Cognitive function was assessed through the CERAD tests, Animal Fluency test, and Digit Symbol Substitution test. Multivariable logistic models and restricted cubic spline models were employed to investigate these associations. This study included a total of 2279 older adults in the United States. Only 11% of adults achieved a high total CVH score, while 12% had a low score. After further adjustment for potential confounding factors, higher LE8 scores were significantly associated with higher scores on CERAD: delayed recall score (0.02[0.01, 0.03]; P < 0.001), CERAD: total score (3 recall trials) (0.04[0.02, 0.06]; P < 0.001), animal fluency: total score (0.09[0.05, 0.12]; P < 0.001), and digit symbol: score (0.29[0.18, 0.41]; P < 0.001), demonstrating a linear dose-response relationship. Similar patterns were also observed in the associations between health behavior and health factor scores with cognitive function tests. LE8 scores exhibited positive linear associations with cognitive function. Maintaining better levels of CVH may be associated with higher levels of cognitive function in older Americans, but further research is needed to confirm the causal and temporal relationships between LE8 and cognitive function.
美国心脏协会（AHA）最近重新定义了心血管健康（CVH），引入了生命必备的 8 项（LE8），其中包括 8 个方面（饮食、身体活动、尼古丁暴露、睡眠时长、体重指数、非高密度脂蛋白胆固醇、血糖和血压）。本研究旨在探讨美国老年人中，LE8 定义的整体和个体 CVH 指标与认知功能之间的关系。这是一项横断面、基于人群的研究，分析了 2011 年至 2014 年期间进行的国家健康和营养检查调查的数据，重点关注 60 岁及以上的个体。CVH 分为低（0-49）、中（50-79）或高（80-100）。认知功能通过 CERAD 测试、动物流畅性测试和数字符号替代测试进行评估。采用多变量逻辑模型和限制立方样条模型来研究这些关联。本研究共纳入了美国 2279 名老年人。只有 11%的成年人获得了高的总 CVH 评分，而 12%的成年人获得了低的 CVH 评分。在进一步调整了潜在混杂因素后，较高的 LE8 评分与 CERAD 测试中的较高得分显著相关：延迟回忆评分（0.02[0.01, 0.03]；P<0.001）、CERAD：总评分（3 次回忆试验）（0.04[0.02, 0.06]；P<0.001）、动物流畅性：总评分（0.09[0.05, 0.12]；P<0.001）和数字符号：评分（0.29[0.18, 0.41]；P<0.001），表现出线性剂量反应关系。在健康行为和健康因素评分与认知功能测试之间的关联中也观察到了类似的模式。LE8 评分与认知功能呈正线性关联。维持更好的 CVH 水平可能与美国老年人更高的认知功能水平相关，但需要进一步的研究来证实 LE8 与认知功能之间的因果和时间关系。
