College of Health Solutions, Arizona State University Downtown Phoenix Campus, Phoenix, AZ, United States.
Sandra Day O'Connor College of Law, Arizona State University, Tempe, AZ, United States.
Int J Public Health. 2024 Aug 6;69:1607165. doi: 10.3389/ijph.2024.1607165. eCollection 2024.
Blood transfusion is an important mode of infectious disease transmission in low- and middle-income countries (LMICs). This study describes a model to determine the prevalence of transfusion-transmitted infections (TTIs) and the associated burden of disease.
A five-step model was developed to determine the TTI-related burden of disease measured by disability-adjusted life years (DALYs). Uganda was selected as the study country.
Approximately 298,266 units of blood were transfused in Uganda in 2019, yielding an estimated TTI incidence of 6,858 new TTIs (2.3% of transfused units) and prevalence of 19,141 TTIs (6.4% of transfused units). The total burden of disease is 2,903 DALYs, consisting of approximately 2,590 years of life lost (YLLs), and 313 years lived with disability (YLDs).
The incidence and prevalence of TTIs and the associated burden of disease can be calculated on a local and national level. The model can be applied by health ministries to estimate the impact of TTIs in order to develop blood safety strategies to reduce the burden of disease.
输血是中低收入国家（LMICs）传染病传播的重要方式。本研究描述了一种确定输血传播感染（TTI）患病率和相关疾病负担的模型。
开发了一个五步模型来确定由残疾调整生命年（DALYs）衡量的 TTI 相关疾病负担。乌干达被选为研究国家。
2019 年乌干达共输注了约 298266 单位的血液，估计新发 TTI 发病率为 6858 例（输注单位的 2.3%），TTI 患病率为 19141 例（输注单位的 6.4%）。疾病总负担为 2903 个 DALYs，包括约 2590 年生命损失（YLLs）和 313 年残疾生存（YLDs）。
可以在地方和国家层面计算 TTI 的发病率和患病率以及相关疾病负担。卫生部可以应用该模型来估计 TTI 的影响，以制定血液安全策略来减轻疾病负担。
