Gilbert-Falardeau Amélie, Drolet Anne-Marie
Department of Dermatology, Université Laval, Québec, Québec, QC, Canada.
Department of Dermatology, Hôtel-Dieu de Lévis, Lévis, Québec, QC, Canada.
SAGE Open Med Case Rep. 2024 Aug 19;12:2050313X241274888. doi: 10.1177/2050313X241274888. eCollection 2024.
Necrobiotic xanthogranuloma is a rare non-Langerhans cell histiocytosis with the potential for multisystemic involvement. It's a challenging disease to treat and multiple treatments have been reported in the literature with variable results. We present the case of a 92-year-old woman with multiple orange-brown papules and plaques on her face progressing for several years. The biopsy showed dermal xanthogranulomatous infiltration with multinucleated giant cells and necrobiosis, and she was diagnosed with necrobiotic xanthogranuloma. A complete response was obtained with intravenous immunoglobulins and she remained in remission despite treatment discontinuation.
渐进性坏死性黄色肉芽肿是一种罕见的非朗格汉斯细胞组织细胞增多症，有可能累及多系统。这是一种治疗具有挑战性的疾病，文献中报道了多种治疗方法，结果各不相同。我们报告了一例92岁女性患者的病例，她面部有多个橙褐色丘疹和斑块，病程长达数年。活检显示真皮有黄色肉芽肿性浸润，伴有多核巨细胞和渐进性坏死，她被诊断为渐进性坏死性黄色肉芽肿。静脉注射免疫球蛋白后获得了完全缓解，尽管停止治疗，她仍处于缓解状态。
