Ziemer Mirjana, Norgauer Johannes, Simon Jan-Christoph, Koehler Martin Johannes
Department of Dermatology, Venereology, and Allergology, University Hospital of Leipzig, Philipp-Rosenthal-Str. 23–25, Leipzig, Germany.
Am J Dermatopathol. 2012 Apr;34(2):e22-6. doi: 10.1097/DAD.0b013e3182222aa8.
Necrobiotic xanthogranuloma (NXG) usually shows a stereotypical histopathologic presentation. However, few unusual cases have been published. We present a patient with NXG showing exceptional histopathologic features. NXG in our patient presents with exclusively dermal granulomatous inflammation mimicking interstitial granuloma annulare. Not only subcutaneous involvement, but also, evident zones of degenerated collagen, foam cells, and cholesterol clefts were missing. Moreover, the case shows overlaps with recently published granulomatous scleromyxedema. Some common clinical and histopathologic features of NXG and scleromyxedema might be based on shared underlying paraproteinemia.
坏死性黄色肉芽肿（NXG）通常表现出典型的组织病理学表现。然而，仅有少数不寻常的病例被报道。我们报告了1例具有特殊组织病理学特征的NXG患者。我们患者的NXG仅表现为模仿环状肉芽肿的真皮肉芽肿性炎症。不仅没有皮下受累，而且也没有明显的胶原退变区、泡沫细胞和胆固醇裂隙。此外，该病例与最近报道的肉芽肿性硬化性黏液水肿有重叠。NXG和硬化性黏液水肿的一些常见临床和组织病理学特征可能基于共同的潜在副蛋白血症。
