Dorff Erika M, Liu Sarah Y, Abu-Jaish Wasef, Abu Alfa Amer K
University of Vermont Medical Center, Burlington, Vermont.
Gastro Hep Adv. 2024 Apr 6;3(5):602-604. doi: 10.1016/j.gastha.2024.04.001. eCollection 2024.
Lanthanum carbonate (LC) is a phosphate binder used in end-stage renal disease (ESRD) with few adverse effects due to poor systemic absorption. Gastrointestinal deposition is likely due to alterations in epithelial permeability from inflammation in ESRD. It is challenging to detect in cases with minimal deposition and may be missed on endoscopy and biopsy. A 36-year-old with ESRD who was evaluated for gastrectomy was found to have LC deposition histologically. Years later, the excised portion had similar findings. This case allows for evaluation of LC gastropathy in a resection specimen, providing the opportunity to showcase its unique pathology features.
碳酸镧（LC）是一种用于终末期肾病（ESRD）的磷结合剂，由于全身吸收不良，其不良反应较少。胃肠道沉积可能是由于ESRD炎症导致上皮通透性改变所致。在沉积极少的病例中进行检测具有挑战性，在内镜检查和活检时可能会漏诊。一名接受胃切除术评估的36岁ESRD患者在组织学上发现有LC沉积。数年后，切除的部分有类似发现。该病例有助于在切除标本中评估LC胃病，为展示其独特的病理特征提供了机会。
