Tonooka Akiko, Uda Susumu, Tanaka Hiroki, Yao Atsushi, Uekusa Toshimasa
Department of Diagnostic Pathology , Kanto Rosai Hospital , Kanagawa , Japan.
Department of Nephrology , Kanto Rosai Hospital , Kanagawa , Japan.
Clin Kidney J. 2015 Oct;8(5):572-5. doi: 10.1093/ckj/sfv062. Epub 2015 Jul 16.
Lanthanum carbonate (LC) is an orally administered phosphate binder. Its absorption is generally thought to be minimal. We report here the case of an 81-year-old woman who underwent subtotal gastrectomy for gastric cancer after receiving hemodialysis for 1 year and taking LC for 7 months. Lanthanum phosphate compounds were found histologically in the gastric mucosa and a regional lymph node and confirmed by scanning and transmission electron microscopy-energy-dispersive X-ray spectroscopy. These findings suggest that lanthanum is absorbed in the stomach and transported via lymph flow. This observation could prove helpful in future investigation of lanthanum disposition.
碳酸镧（LC）是一种口服磷结合剂。一般认为其吸收极少。我们在此报告一例81岁女性病例，该患者在接受1年血液透析并服用LC 7个月后因胃癌接受了胃大部切除术。在胃黏膜和局部淋巴结中经组织学检查发现了磷酸镧化合物，并通过扫描和透射电子显微镜-能量色散X射线光谱法得以证实。这些发现表明镧在胃中被吸收并通过淋巴液流动运输。这一观察结果可能对未来镧处置的研究有所帮助。
