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伴有严重贫血的空肠胃肠道间质瘤

Jejunal gastrointestinal stromal tumor (GIST) with profound anemia.

作者信息

Huynh Amelia T, Rust Ann

机构信息

Department of Surgery, Good Shepherd Health Care System, 610 NW 11th St., Hermiston, OR 97838, United States.

School of Osteopathic Medicine, Pacific Northwest University of Health Sciences, Butler-Haney Hall, 200 University Pkwy, Yakima, WA 98901, United States.

出版信息

J Surg Case Rep. 2024 Aug 20;2024(8):rjae497. doi: 10.1093/jscr/rjae497. eCollection 2024 Aug.

DOI:10.1093/jscr/rjae497
PMID:39165609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334061/
Abstract

Gastrointestinal stromal tumors (GISTs) are uncommon tumors typically found in the stomach, with an even rarer appearance in the jejunum. These tumors are often discovered incidentally, given their nonspecific presentation. We present a case of chronic iron deficiency anemia in a patient with symptomatic GIST involving the proximal jejunum requiring robot-assisted resection with primary anastomosis. Pathological examination of the excised GIST revealed positive immunoreactivity for cKIT, DOG1, and CD37. This case highlights the importance of considering GIST as a differential diagnosis for chronic anemia and emphasizes the critical role of CT imaging in its detection and management.

摘要

胃肠道间质瘤(GISTs)是罕见肿瘤,通常见于胃,在空肠出现则更为罕见。这些肿瘤因其临床表现不具特异性,常为偶然发现。我们报告一例有症状的GIST累及空肠近端的患者出现慢性缺铁性贫血,需行机器人辅助切除并一期吻合术。切除的GIST病理检查显示cKIT、DOG1和CD37免疫反应呈阳性。该病例突出了将GIST作为慢性贫血鉴别诊断的重要性,并强调了CT成像在其检测和管理中的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c46/11334061/f23410816b18/rjae497f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c46/11334061/f23410816b18/rjae497f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c46/11334061/f23410816b18/rjae497f1.jpg

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本文引用的文献

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Jejunal Gastrointestinal Stromal Tumor: A Diagnostic Challenge.空肠胃肠道间质瘤:一项诊断挑战。
Cureus. 2023 Apr 25;15(4):e38098. doi: 10.7759/cureus.38098. eCollection 2023 Apr.
2
Computed tomography enteroclysis combined with double-balloon endoscopy is beneficial to the diagnosis of small bowel submucosal tumors.计算机断层扫描小肠造影联合双气囊小肠镜检查有助于小肠黏膜下肿瘤的诊断。
Am J Transl Res. 2023 Apr 15;15(4):2836-2842. eCollection 2023.
3
Sex differences in patients with gastrointestinal stromal tumours: do they exist and does it affect survival?
胃肠道间质瘤患者的性别差异:是否存在差异,是否影响生存?
ESMO Open. 2022 Dec;7(6):100649. doi: 10.1016/j.esmoop.2022.100649. Epub 2022 Dec 6.
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NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.NCCN 指南洞察版:胃肠道间质瘤,2022 年第 2 版。
J Natl Compr Canc Netw. 2022 Nov;20(11):1204-1214. doi: 10.6004/jnccn.2022.0058.
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Diagnostic and Therapeutic Challenges in the Management of Acute Massive Overt Bleeding of Jejunal Gastrointestinal Stromal Tumours: Case Series.空肠胃肠道间质瘤急性大量显性出血管理中的诊断与治疗挑战:病例系列
J Gastrointest Cancer. 2023 Mar;54(1):316-322. doi: 10.1007/s12029-021-00650-w. Epub 2022 Feb 24.
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Gastrointestinal Stromal Tumors of the Small Intestine: Progress in Diagnosis and Treatment Research.小肠胃肠道间质瘤:诊断与治疗研究进展
Cancer Manag Res. 2020 May 25;12:3877-3889. doi: 10.2147/CMAR.S238227. eCollection 2020.
7
Primary Jejunal Gastrointestinal Stromal Tumor: Diagnosis Delay of 3 Years but Successful Management in Early Stage (II) by Surgery and Adjuvant Therapy.原发性空肠胃肠道间质瘤:诊断延误3年,但早期(II期)通过手术及辅助治疗成功治愈
Gastrointest Tumors. 2019 Aug;6(1-2):36-42. doi: 10.1159/000496973. Epub 2019 Apr 3.
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Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients.胃肠道间质瘤:47 例连续患者的临床表现、肿瘤部位和预后因素的相关性。
World J Surg Oncol. 2011 Feb 1;9:13. doi: 10.1186/1477-7819-9-13.