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舌下给药的细菌裂解物：基本原理、作用机制及临床结果。

Sublingually administered bacterial lysates: rationale, mechanisms of action and clinical outcomes.

作者信息

Braido Fulvio, Melioli Giovanni, Nicolini Gabriele, Ferraris Melissa, Di Girolamo Stefano, Di Gioacchino Mario, Canonica Giorgio Walter

机构信息

IRCCS Ospedale Policlinico San Martino, Italy.

Università di Genova, DiMI, Genoa, Italy.

出版信息

Drugs Context. 2024 Aug 7;13. doi: 10.7573/dic.2024-1-5. eCollection 2024.

DOI:10.7573/dic.2024-1-5
PMID:39165613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335356/
Abstract

This review discusses available evidence on the mechanisms of action of bacterial lysates, and the clinical effects of their sublingual administration. Bacterial lysates act through many immunological effects, including dendritic cell activation, modification of circulating lymphocyte subsets and antibody production. The production of salivary IgA was repeatedly shown to be induced by the sublingual administration of a prototype bacterial lysate containing soluble and corpuscular antigens. Bacterial lysates are a useful tool for the prevention of recurrent respiratory tract infections. Sublingual administration should be the preferred option.

摘要

本综述讨论了关于细菌裂解物作用机制的现有证据，以及其舌下给药的临床效果。细菌裂解物通过多种免疫效应发挥作用，包括树突状细胞激活、循环淋巴细胞亚群的改变以及抗体产生。舌下给予含有可溶性和颗粒性抗原的原型细菌裂解物反复显示可诱导唾液IgA的产生。细菌裂解物是预防复发性呼吸道感染的有用工具。舌下给药应是首选方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/d7b72887431b/DIC-2024-1-5_MELIOLI_Figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/9cbe9ab43788/DIC-2024-1-5_MELIOLI_Figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/f2434614b76c/DIC-2024-1-5_MELIOLI_Figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/d7b72887431b/DIC-2024-1-5_MELIOLI_Figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/9cbe9ab43788/DIC-2024-1-5_MELIOLI_Figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/f2434614b76c/DIC-2024-1-5_MELIOLI_Figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1842/11335356/d7b72887431b/DIC-2024-1-5_MELIOLI_Figure_3.jpg

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J Leukoc Biol. 2023 May 2;113(5):535-540. doi: 10.1093/jleuko/qiad003.
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