Wei Lisha
School of Marine and Biological Engineering, Yancheng Teachers University, Yancheng, Jiangsu, China.
Heliyon. 2024 Jul 26;10(15):e35265. doi: 10.1016/j.heliyon.2024.e35265. eCollection 2024 Aug 15.
The deletion of geranylgeranyl diphosphate synthase 1 () has been reported to inhibit the proliferation of multiple cells. Although emerging evidence has demonstrated a correlation between and cancer, no pan-cancer analysis has been conducted to date. This study explored the potential tumorigenesis of using data from the cancer genome atlas human clinical database. expression was considerably upregulated at both the RNA and protein levels in several cancer types, especially in breast carcinoma (BRCA), (liver) hepatocellular carcinoma (LIHC/HCC) and lung adenocarcinoma (LUAD). Amplification is the most common form of genetic alteration observed in invasive BRCA, ovarian epithelial tumor and HCC. Additionally, elevated expression was markedly related to poor patient prognosis and overall survival in several cancer types including LIHC. expression was also linked to cancer-associated fibroblasts (CAFs) infiltration in several cancer types, such as BRCA and LUAD. Moreover, GGPPS-interacting proteins and correlated genes in cancers were functionally enriched in terpenoid backbone biosynthesis, steroid biosynthesis, and metabolic pathways. These results indicate that may play a role in promoting the tumorigenesis and tumor development, particularly in BRCA and LUAD, and may play a role in steroid biosynthesis and metabolic pathways.
据报道，香叶基香叶基二磷酸合酶1（GGPPS1）的缺失会抑制多种细胞的增殖。尽管新出现的证据表明GGPPS1与癌症之间存在关联，但迄今为止尚未进行全癌分析。本研究利用癌症基因组图谱人类临床数据库的数据探索了GGPPS1的潜在肿瘤发生机制。在几种癌症类型中，尤其是在乳腺癌（BRCA）、（肝）肝细胞癌（LIHC/HCC）和肺腺癌（LUAD）中，GGPPS1的RNA和蛋白质水平均显著上调。扩增是在浸润性BRCA、卵巢上皮肿瘤和HCC中观察到的最常见的基因改变形式。此外，在包括LIHC在内的几种癌症类型中，GGPPS1表达升高与患者预后不良和总生存期显著相关。在几种癌症类型中，如BRCA和LUAD，GGPPS1表达还与癌症相关成纤维细胞（CAF）浸润有关。此外，癌症中与GGPPS相互作用蛋白和相关基因在萜类骨架生物合成、类固醇生物合成和代谢途径中功能富集。这些结果表明，GGPPS1可能在促进肿瘤发生和肿瘤发展中起作用，尤其是在BRCA和LUAD中，并且可能在类固醇生物合成和代谢途径中起作用。
