Saravanan K A, Panigrahi Manjit, Kumar Harshit, Nayak Sonali Sonejita, Rajawat Divya, Bhushan Bharat, Dutt Triveni
Division of Animal Genetics, Indian Veterinary Research Institute, Bareilly, UP, India.
Livestock Production and Management Section, Indian Veterinary Research Institute, Bareilly, UP, India.
Anim Biotechnol. 2023 Nov;34(6):1979-1987. doi: 10.1080/10495398.2022.2056046. Epub 2022 Apr 4.
The field of genetics has evolved a lot after the emergence of molecular and advanced genomic technologies. The advent of Next Generation Sequencing, SNP genotyping platforms and simultaneous reduction in the cost of sequencing had opened the door to genomic research in farm animals. There are various applications of genomics in livestock, such as the use of genomic data: (i) to investigate genetic diversity and breed composition/population structure (ii) to identify genetic variants and QTLs related to economically important and ecological traits, genome-wide association studies (GWAS) and genomic signatures of selection; (iii) to enhance breeding programs by genomic selection. Compared to traditional methods, genomic selection is expected to improve selection response by increasing selection accuracy and reducing the generation interval due to early selection. Genomic selection (GS) in developed countries has led to rapid genetic gains, especially in dairy cattle, due to a well-established genetic evaluation system. Indian livestock system is still lagging behind developed nations in adopting these technologies. This review discusses the current status, challenges, and future perspectives of livestock genomics in India.
自分子和先进基因组技术出现以来,遗传学领域有了很大发展。新一代测序技术、单核苷酸多态性(SNP)基因分型平台的出现以及测序成本的同步降低,为家畜基因组研究打开了大门。基因组学在畜牧业中有多种应用,例如利用基因组数据:(i)调查遗传多样性和品种组成/种群结构;(ii)识别与经济重要性状和生态性状相关的遗传变异和数量性状位点(QTL)、全基因组关联研究(GWAS)以及选择的基因组特征;(iii)通过基因组选择加强育种计划。与传统方法相比,基因组选择有望通过提高选择准确性和缩短因早期选择导致的世代间隔来改善选择反应。由于建立了完善的遗传评估系统,发达国家的基因组选择(GS)已带来快速的遗传进展,尤其是在奶牛方面。印度畜牧系统在采用这些技术方面仍落后于发达国家。本综述讨论了印度家畜基因组学的现状、挑战和未来前景。