Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China.
Fa Yi Xue Za Zhi. 2024 Jun 25;40(3):276-283. doi: 10.12116/j.issn.1004-5619.2023.330802.
Piperazines are a class of new psychoactive substances with hallucinogenic effects that affect the central nervous system by affecting the level of monoamine neurotransmitters. Abuse of piperazines will produce stimulating and hallucinogenic effects, accompanied by headache, dizziness, anxiety, insomnia, vomiting, chest pain, tachycardia, hypertension and other adverse reactions, and may even cause cardiovascular diseases and multiple organ failure and lead to death, seriously affecting human physical and mental health and public safety. The abuse of new psychoactive substance piperazines has attracted extensive attention from the international community. The study of its pharmacological toxicology and analytical methods has become a research hotspot in the field of forensic medicine. This paper reviews the processes, sample treatment and analytical methods of existing piperazines, in order to provide reference for forensic identification.
哌嗪类是一类具有致幻作用的新型精神活性物质，通过影响单胺类神经递质的水平来影响中枢神经系统。滥用哌嗪类会产生兴奋和致幻作用，伴有头痛、头晕、焦虑、失眠、呕吐、胸痛、心动过速、高血压等不良反应，甚至可能导致心血管疾病和多器官衰竭而死亡，严重影响人类身心健康和公共安全。新型精神活性物质哌嗪的滥用引起了国际社会的广泛关注，其药理学毒理学和分析方法的研究已成为法医学领域的研究热点。本文综述了哌嗪类的现有分析方法及其样品前处理过程，以期为法医学鉴定提供参考。
