Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, León, Guanajuato, México.
Neuroreport. 2024 Oct 16;35(15):992-999. doi: 10.1097/WNR.0000000000002090. Epub 2024 Aug 13.
This study aimed to compare the effect of the early postmenopausal period on resting-state electroencephalographic spectral power with that of the premenopausal period and to analyze the correlation between electroencephalographic spectral power values and endogenous ovarian hormone levels. This study involved 13 early postmenopausal women and 10 premenopausal women in the early follicular, 10 in the ovulatory phase, and 10 in the early luteal phase who underwent resting-state quantitative electroencephalographic spectral power with eyes closed and endogenous ovarian hormone measurements. The delta, theta, alpha1, alpha2, beta1, and beta2 absolute power were compared between the early postmenopausal and premenopausal groups. Correlations between electroencephalographic spectral power values and 17β estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone levels were analyzed in early postmenopausal women. Compared with the premenopausal group, the early postmenopausal group showed significantly higher resting-state theta power in the frontal region, alpha1 and alpha2 power in the frontal and central regions, beta1 power in the frontal, central, parietal, and occipital regions, and beta2 power in the centroparietal region. Beta2 power values were positively correlated with FSH levels. The current findings highlight that early postmenopausal women show greater resting-state alpha and beta power, which suggests cortical excitability of fast frequency bands involved in states of alertness, focus of attention, cognition, and emotion. Additionally, we emphasized the effect of FSH levels on fast cortical activation in early postmenopausal women.
本研究旨在比较早绝经后与绝经前静息状态脑电图（EEG）频谱功率的差异，并分析 EEG 频谱功率值与内源性卵巢激素水平之间的相关性。本研究纳入了 13 名早绝经后女性和 10 名早卵泡期、10 名排卵期和 10 名早黄体期的绝经前女性，所有受试者均接受闭眼静息状态定量 EEG 频谱功率和内源性卵巢激素检测。比较了早绝经后组和绝经前组的 delta、theta、alpha1、alpha2、beta1 和 beta2 绝对功率。分析了早绝经后女性的 EEG 频谱功率值与 17β 雌二醇、孕酮、促卵泡激素（FSH）和黄体生成素水平之间的相关性。与绝经前组相比，早绝经后组在额区的静息状态 theta 功率、额区和中央区的 alpha1 和 alpha2 功率、额区、中央区、顶区和枕区的 beta1 功率以及中央顶区的 beta2 功率均显著升高。beta2 功率值与 FSH 水平呈正相关。本研究结果表明，早绝经后女性的静息状态 alpha 和 beta 功率增加，提示与警觉、注意力集中、认知和情绪相关的快频带皮质兴奋性增加。此外，我们强调了 FSH 水平对早绝经后女性快速皮质激活的影响。
