Department of Immunology, School of Medicine, Aja University of Medical Sciences, Tehran, IR Iran.
Department of Infectious Diseases, School of Medicine, Aja University of Medical Sciences, Tehran, IR Iran.
Arch Physiol Biochem. 2020 Oct;126(4):335-340. doi: 10.1080/13813455.2018.1538248. Epub 2018 Nov 21.
Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group. In addition, Subfatin demonstrated lower levels in obese patients with T2DM in comparison to lean T2DM patients. Furthermore, Subfatin showed a negative association with vascular adhesion molecules in prediabetes subjects and the T2DM group. A decrease in the serum Subfatin in T2DM patients and prediabetes subjects, and its association with vascular adhesion molecules suggested the possible role of Subfatin in diabetes and endothelial dysfunction.
Subfatin 是一种新发现的脂肪因子，具有胰岛素增敏作用。有研究报道，在 2 型糖尿病（T2DM）和肥胖症的背景下，Subfatin 的循环水平和表达存在矛盾的数据。本研究纳入了 52 例 T2DM 患者、36 例糖尿病前期患者和 50 例对照者。采用 ELISA 技术检测血清 Subfatin 和黏附分子水平。T2DM 和糖尿病前期组的血清 Subfatin 水平较低。T2DM 组血清黏附分子水平较高。此外，与非肥胖的 T2DM 患者相比，肥胖的 T2DM 患者的血清 Subfatin 水平更低。此外，在糖尿病前期患者和 T2DM 组中，Subfatin 与血管黏附分子呈负相关。T2DM 患者和糖尿病前期患者血清 Subfatin 水平下降，与血管黏附分子相关，提示 Subfatin 可能在糖尿病和内皮功能障碍中发挥作用。
