载脂蛋白 E（APOE）、脂肪因子瘦素（FTO）和脂蛋白脂肪酶（LPL）等代谢基因在心房颤动发生中的作用：病例对照研究的启示。
Contributing role of metabolic genes APOE, FTO, and LPL in the development of atrial fibrillation: insights from a case-control study.
机构信息
Lahore College for Women University, Department of Zoology - Lahore, Pakistan.
Aristotle University of Thessaloniki, General Hospital "Hippokration", Second Department of Cardiology, Outpatient Department of Cardiometabolic Medicine - Thessaloniki, Greece.
出版信息
Rev Assoc Med Bras (1992). 2024 Aug 16;70(8):e20240263. doi: 10.1590/1806-9282.20240263. eCollection 2024.
OBJECTIVE
The aim of the study was to examine the expression profile of genes (APOE, FTO, and LPL) associated with metabolic syndrome (MetS) in subjects with concomitant atrial fibrillation (AF).
METHODS
A total of 690 subjects were categorized into control, AF without MetS, and AF with MetS.
RESULTS
The expression profiles of the APOE, FTO, and LPL genes were decreased in AF subjects and AF subjects with MetS as compared to the controls. In AF without the MetS group, an inverse relationship was found between the expression of the LPL gene with body mass index (BMI) and a positive relationship with creatine kinase-MB, whereas expression of the FTO gene was inversely associated with fasting blood glucose and positively with cardiac troponin I in AF suffering from MetS. Expression of the LPL gene was directly linked with systolic blood pressure (SBP) and high-density lipoprotein-cholesterol (HDL-C), whereas an inverse correlation with heart rate and expression of the FTO gene in AF with MetS were shown. The expression of the LPL gene was inversely related to BMI in subjects with AF. The expression of the LPL gene was positively correlated with SBP and HDL-C and negatively correlated with heart rate, while the expression of the FTO gene was an important predictor of AF with MetS.
CONCLUSION
The decreased expression of APOE, FTO, and LPL genes in AF with and without MetS indicates their potential contributing role in the pathogenesis of AF.
目的
本研究旨在探讨代谢综合征（MetS）合并心房颤动（AF）患者中与代谢综合征相关的基因（APOE、FTO 和 LPL）的表达谱。
方法
共纳入 690 例患者，分为对照组、无 MetS 的 AF 组和有 MetS 的 AF 组。
结果
与对照组相比，AF 患者和合并 MetS 的 AF 患者的 APOE、FTO 和 LPL 基因表达谱降低。在无 MetS 的 AF 组中，LPL 基因的表达与体重指数（BMI）呈负相关，与肌酸激酶同工酶-MB（creatine kinase-MB）呈正相关，而 FTO 基因的表达与空腹血糖呈负相关，与心肌肌钙蛋白 I（cardiac troponin I）呈正相关。LPL 基因的表达与收缩压（systolic blood pressure，SBP）和高密度脂蛋白胆固醇（high-density lipoprotein-cholesterol，HDL-C）呈正相关，与心率呈负相关，而 FTO 基因在合并 MetS 的 AF 患者中与上述指标呈负相关。在 AF 患者中，LPL 基因的表达与 BMI 呈负相关。LPL 基因的表达与 SBP 和 HDL-C 呈正相关，与心率呈负相关，而 FTO 基因是 MetS 合并 AF 的重要预测因子。
结论
在有或无 MetS 的 AF 患者中，APOE、FTO 和 LPL 基因表达降低，表明它们可能在 AF 的发病机制中发挥作用。
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