Zhou Lujia, Fan Shiying, Zhang Wenjie, Gong Zhiyuan, Wang Daorong, Tang Dong
Department of Clinical Medicine, Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu, China.
School of Medicine, Chongqing University, Chongqing, 400030, China.
Clin Transl Oncol. 2025 Mar;27(3):871-886. doi: 10.1007/s12094-024-03650-x. Epub 2024 Aug 21.
The process by which living cells are phagocytosed and digested to death is called cell death by phagocytosis, a term that has just recently been generalized and redefined. It is characterized by the phagocytosis of living cells and the cessation of cell death by phagocytosis. Phagocytosis of dead cells is a widely discussed issue in cancer, cell death by phagocytosis can stimulate phagocytosis and stimulate adaptive immunity in tumors, and at the same time, do not-eat-me signaling is an important site for cancer cells to evade recognition by phagocytes. Therefore, we discuss in this review cell death by phagocytosis occurring in cancer tissues and emphasize the difference between this new concept and the phagocytosis of dead tumor cells. Immediately thereafter, we describe the mechanisms by which cell death by phagocytosis occurs and how tumors escape phagocytosis. Finally, we summarize the potential clinical uses of cell death by phagocytosis in tumor therapy and strive to provide ideas for tumor therapy.
活细胞被吞噬并消化致死的过程称为吞噬性细胞死亡，这一术语最近才被普遍化和重新定义。其特征在于活细胞的吞噬作用以及吞噬性细胞死亡的停止。死细胞的吞噬作用是癌症中一个广泛讨论的问题，吞噬性细胞死亡可刺激肿瘤中的吞噬作用并激发适应性免疫，同时，“别吃我”信号是癌细胞逃避吞噬细胞识别的重要位点。因此，我们在本综述中讨论癌症组织中发生的吞噬性细胞死亡，并强调这一新概念与死肿瘤细胞吞噬作用之间的差异。紧接着，我们描述吞噬性细胞死亡发生的机制以及肿瘤如何逃避吞噬作用。最后，我们总结吞噬性细胞死亡在肿瘤治疗中的潜在临床应用，并努力为肿瘤治疗提供思路。
