School of Medical Imaging, Xuzhou Medical University, Xuzhou, China.
Biotechnol J. 2024 Aug;19(8):e2400325. doi: 10.1002/biot.202400325.
Microalgae are a group of microorganisms containing chlorophyll A, which are highly photosynthetic and rich in nutrients. And they can produce multiple bioactive substances (peptides, proteins, polysaccharides, and fatty acids) for biomedical applications. Despite the unique advantages of microalgae-based biotherapy, the insufficient treatment efficiency limits its further application. With the development of nanotechnology, the combination of microalgae and biomaterials can improve therapeutic efficacies, which has attracted increasing attention. In this microalgal-biomaterials hybrid system, biomaterials with excellent optical and magnetic properties play an important role in biological therapy. Microalgae, as a natural vehicle, can increase oxygen content and alleviate hypoxia in diseased areas, further enhancing therapeutic effects. In this review, the synergistic therapeutic effects of microalgal-biomaterials hybrid system in different diseases (cancer, myocardial infarction, ischemia stroke, chronic infection, and intestinal diseases) are comprehensively summarized.
微藻是一群含有叶绿素 A 的微生物，具有高度的光合作用和丰富的营养成分。它们可以产生多种生物活性物质（肽、蛋白质、多糖和脂肪酸），用于生物医学应用。尽管基于微藻的生物疗法具有独特的优势，但治疗效率不足限制了其进一步的应用。随着纳米技术的发展，微藻与生物材料的结合可以提高治疗效果，这引起了越来越多的关注。在这种微藻-生物材料混合系统中，具有优异光学和磁性的生物材料在生物治疗中发挥着重要作用。微藻作为一种天然载体，可以增加氧气含量，减轻患病区域的缺氧，进一步增强治疗效果。在这篇综述中，全面总结了微藻-生物材料混合系统在不同疾病（癌症、心肌梗死、缺血性中风、慢性感染和肠道疾病）中的协同治疗效果。
