Department of Burns and Plastic Surgery, Shanghai Changzheng Hospital, Shanghai, 200003, People's Republic of China.
Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China.
Int J Nanomedicine. 2022 Jul 15;17:3101-3122. doi: 10.2147/IJN.S368763. eCollection 2022.
Hypoxia can aggravate the conditions of many oxygen-deficiency-aggravated diseases (ODAD), such as cancer, ischemic heart disease, and chronic wounds. Photosynthetic microalgae can alleviate the hepatotoxicity of the local microenvironment by producing oxygen. In addition, microalgae extracts have antitumor, anti-inflammatory, antibacterial, and antioxidant effects. These properties make them attractive candidates for developing methods to treat ODAD. Although researchers have exploited the advantages of microalgae and developed a variety of microalgae-based biomaterials to treat ODAD, a comprehensive review of this topic has not been presented previously. Therefore, in this review, we summarize the development and progress made in the field of developing microalgae-based biomaterials toward the treatment of ODAD. The challenges and prospects of this field are also discussed.
缺氧会加重许多缺氧加重疾病（ODAD）的病情，如癌症、缺血性心脏病和慢性创伤。光合微藻通过产生氧气来减轻局部微环境的肝毒性。此外，微藻提取物具有抗肿瘤、抗炎、抗菌和抗氧化作用。这些特性使它们成为治疗 ODAD 的有吸引力的候选方法。尽管研究人员已经利用微藻的优势开发了多种基于微藻的生物材料来治疗 ODAD，但以前没有对这个主题进行全面的综述。因此，在这篇综述中，我们总结了开发基于微藻的生物材料治疗 ODAD 方面的发展和进展。还讨论了该领域的挑战和前景。
