Cerra F B
University of Minnesota, Minneapolis.
Crit Care Clin. 1985 Nov;1(3):591-607.
Sepsis, which is the host response to one or more microorganisms, is probably best understood within the concept of activator-mediator-responder. The various forms of metabolic support work in all three areas. The best treatment is still prevention. The mortality rate has progressively fallen and is now in the range of 35 to 40 per cent. Appropriate nutritional support seems to have been an important factor in this reduction in mortality. There are many new areas of research that need to be evaluated, and many of these areas are now directed at regulatory aspects of the metabolic response.
脓毒症是机体对一种或多种微生物的反应，或许在激活物-介质-反应者的概念框架内最易理解。各种形式的代谢支持在所有这三个方面都发挥作用。最佳治疗仍然是预防。死亡率已逐步下降，目前在35%至40%的范围内。适当的营养支持似乎是死亡率降低的一个重要因素。有许多新的研究领域需要评估，其中许多领域目前针对代谢反应的调节方面。
