Service of Infectious Diseases, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain.
Service of Infectious Diseases, Reina Sofia University Hospital. Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Córdoba, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Transplant Rev (Orlando). 2024 Dec;38(4):100875. doi: 10.1016/j.trre.2024.100875. Epub 2024 Aug 5.
Cytomegalovirus (CMV) infection remains a significant challenge in solid organ transplantation (SOT). The last international consensus guidelines on the management of CMV in SOT were published in 2018, highlighting the need for revision to incorporate recent advances, notably in cell-mediated immunity monitoring, which could alter the current standard of care. A working group including members from the Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Society of Transplantation (SET), developed consensus-based recommendations for managing CMV infection in SOT recipients. Recommendations were classified based on evidence strength and quality using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The final recommendations were endorsed through a consensus meeting and approved by the expert panel.
巨细胞病毒（CMV）感染仍然是实体器官移植（SOT）中的一个重大挑战。2018 年发表了最后一次关于 SOT 中 CMV 管理的国际共识指南，强调需要进行修订以纳入最近的进展，特别是细胞介导免疫监测方面的进展，这可能会改变当前的护理标准。一个工作组包括来自移植和免疫功能低下宿主感染研究小组（GESITRA-IC）和西班牙传染病和临床微生物学学会（SEIMC）以及西班牙移植学会（SET）的成员，制定了基于共识的 SOT 受者 CMV 感染管理建议。建议根据证据强度和质量使用推荐评估、制定和评估（GRADE）系统进行分类。最终建议通过共识会议得到认可，并得到专家小组的批准。
