Parlak Ayşe Eda, Erdem Toslak Iclal, Turkoglu Selcuk Nursel
Radiology, Health Sciences University Antalya Training and Research Hospital, Antalya, Türkiye.
Pulmonology, Health Sciences University Antalya Training and Research Hospital, Antalya, Türkiye.
Rofo. 2025 Jun;197(6):648-656. doi: 10.1055/a-2369-8377. Epub 2024 Aug 21.
To measure hepatic steatosis (HS) in hospitalized COVID-19 patients using unenhanced chest computed tomography (CT) imaging and to evaluate the relationship between disease severity and prognosis in adult patients.This retrospective study included 152 consecutive hospitalized COVID-19 patients with a positive reverse transcriptase polymerase chain reaction (RT-PCR) test. The COVID-19 Reporting and Data System (CO-RADS) and the chest CT score were evaluated. HS measurements were performed based on CT images using a single region of interest placed on the right liver lobe (segments V-VII). HS was defined as a liver attenuation value <40 Hounsfield units. Data were collected and compared with the patients' prognostic parameters.Of the 152 inpatients, 137 patients (90.1%) had a CT score ≥3 and 109 patients (71.7%) had a CO-RADS score ≥4, 43 (28.2%) had HS. All patients with HS (100%) and 94/109 (86.2%) patients without HS had a CT score ≥3. There was a statistically significant difference between the two groups in terms of chest CT score (p=0.006). There was no statistically significant difference between the two groups in terms of CO-RADS score (p=0.291). The median CRP levels were significantly increased in patients with HS compared to patients without HS (p=0.023). There was no significant difference in ICU hospitalization and mortality due to the presence of HS (p>0.05).The current study revealed significantly higher chest CT scores in COVID-19 patients with HS measured on CT compared to those without HS. Opportunistic use of CT images for the detection of HS can be considered as an adjunctive tool in the risk analysis of COVID-19 patients hospitalized due to COVID-19 pneumonia.The severity of COVID-19 disease is increased in hospitalized patients with hepatosteatosis compared to patients with a normal liver. Density measurements for the evaluation of HS using opportunistic CT applications can be considered as an adjunctive tool in the prognostic evaluation of hospitalized patients with COVID-19 pneumonia. · Parlak AE, Erdem Toslak İ, Turkoglu Selcuk N. Can Opportunistic Use of Computed Tomography Help Reveal the Association Between Hepatic Steatosis and Disease Severity in Hospitalized COVID-19 Patients?. Rofo 2025; 197: 648-656.
使用胸部平扫计算机断层扫描（CT）成像测量住院COVID-19患者的肝脂肪变性（HS），并评估成年患者疾病严重程度与预后之间的关系。这项回顾性研究纳入了152例连续住院的COVID-19患者，其逆转录聚合酶链反应（RT-PCR）检测呈阳性。评估了COVID-19报告和数据系统（CO-RADS）及胸部CT评分。基于CT图像，在右肝叶（V-VII段）放置单个感兴趣区进行HS测量。HS定义为肝脏衰减值<40亨氏单位。收集数据并与患者的预后参数进行比较。152例住院患者中，137例（90.1%）CT评分≥3，109例（71.7%）CO-RADS评分≥4，43例（28.2%）有HS。所有有HS的患者（100%）和94/109例（86.2%）无HS的患者CT评分≥3。两组在胸部CT评分方面存在统计学显著差异（p=0.006）。两组在CO-RADS评分方面无统计学显著差异（p=0.291）。与无HS的患者相比，有HS的患者中C反应蛋白（CRP）水平中位数显著升高（p=0.023）。HS的存在与否在ICU住院率和死亡率方面无显著差异（p>0.05）。本研究显示，与无HS的COVID-19患者相比，CT测量有HS的COVID-19患者胸部CT评分显著更高。对CT图像进行机会性利用以检测HS可被视为对因COVID-19肺炎住院的COVID-19患者进行风险分析的辅助工具。与肝脏正常的患者相比，住院的肝脂肪变性患者中COVID-19疾病的严重程度增加。利用机会性CT应用评估HS的密度测量可被视为对住院COVID-19肺炎患者进行预后评估的辅助工具。·Parlak AE，Erdem Toslak İ，Turkoglu Selcuk N。计算机断层扫描的机会性利用能否有助于揭示住院COVID-19患者肝脂肪变性与疾病严重程度之间的关联？。《德国放射学》2025年；197：648-656。
